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SuperNoder:一种用于发现网络中过度表示的模块化结构的工具。

SuperNoder: a tool to discover over-represented modular structures in networks.

机构信息

Department of Mathematics and Computer Science, University of Cagliari, Cagliari, 09124, Italy.

Department of Computer Science, Courant Institute of Mathematical Sciences, New York University, New York City, 10012, USA.

出版信息

BMC Bioinformatics. 2018 Sep 10;19(1):318. doi: 10.1186/s12859-018-2350-8.

Abstract

BACKGROUND

Networks whose nodes have labels can seem complex. Fortunately, many have substructures that occur often ("motifs"). A societal example of a motif might be a household. Replacing such motifs by named supernodes reduces the complexity of the network and can bring out insightful features. Doing so repeatedly may give hints about higher level structures of the network. We call this recursive process Recursive Supernode Extraction.

RESULTS

This paper describes algorithms and a tool to discover disjoint (i.e. non-overlapping) motifs in a network, replacing those motifs by new nodes, and then recursing. We show applications in food-web and protein-protein interaction (PPI) networks where our methods reduce the complexity of the network and yield insights.

CONCLUSIONS

SuperNoder is a web-based and standalone tool which enables the simplification of big graphs based on the reduction of high frequency motifs. It applies various strategies for identifying disjoint motifs with the goal of enhancing the understandability of networks.

摘要

背景

具有标签的节点的网络可能看起来很复杂。幸运的是,许多网络都具有经常出现的子结构(“motifs”)。社会中的 motif 示例可能是家庭。通过将这些 motif 替换为名节点,可以降低网络的复杂性,并揭示出有洞察力的特征。反复执行此操作可能会提示有关网络更高层次结构的信息。我们将这个递归过程称为递归超级节点提取。

结果

本文描述了用于在网络中发现不相交(即不重叠) motif 的算法和工具,通过将这些 motif 替换为新节点,然后递归处理。我们展示了在食物网和蛋白质-蛋白质相互作用(PPI)网络中的应用,我们的方法降低了网络的复杂性,并提供了深入的见解。

结论

SuperNoder 是一个基于网页的独立工具,它可以基于减少高频 motif 来简化大型图形。它应用了各种策略来识别不相交的 motif,旨在增强对网络的理解。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/09b8/6131773/b131d5ba500b/12859_2018_2350_Fig1_HTML.jpg

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