McNeely Christian, Zajarias Alan, Fohtung Raymond, Kakouros Nikolaos, Walker Jennifer, Robbs Randall, Markwell Stephen, Vassileva Christina M
Department of Medicine, Washington University School of Medicine, St. Louis, Missouri.
Cardiovascular Division, Washington University School of Medicine, St. Louis, Missouri.
Am J Cardiol. 2018 Aug 1;122(3):440-445. doi: 10.1016/j.amjcard.2018.04.019. Epub 2018 May 1.
Racial disparities in the outcomes after intervention for aortic valve disease remain understudied. We stratified patients by race who underwent surgical aortic valve replacement (SAVR) and transcatheter aortic valve implantation (TAVI) in the Medicare database. The TAVI cohort consisted of 17,973 patients (3.9% were black and 1.0% were Hispanic). The SAVR cohort consisted of 95,078 patients, (4.8% were black and 1.3% were Hispanic). Most comorbidities were more common in blacks. After TAVI, 30-day mortality was not significantly different in races with both unadjusted and adjusted data. There were no significant racial differences in readmission rates or discharge to home after TAVI. After SAVR, black patients had worse unadjusted 30-day and 1-year mortality than whites or Hispanics (30-day mortality, 4.7% vs 6.2% vs 4.7% for whites, blacks, and Hispanics, respectively, p = 0.0001; 1-year mortality 11.7% vs 16.1% vs 12.5%, respectively, p = 0.0001); however, after adjustment, there were no differences in mortality. Black patients had higher 30-day readmission rates after SAVR (20.1% vs 25.2% vs 21.7% for whites, blacks, and Hispanics, respectively, p = 0.0001), which persisted after adjustment for comorbidities. Minorities were underrepresented in both SAVR and TAVI relative to what would be predicted by population prevalence. In conclusion, while blacks have worse outcomes in SAVR compared with whites or Hispanics, race did not impact mortality, readmission, or discharge to home in TAVI. Both blacks and Hispanics were underrepresented compared with what would be predicted by population prevalence.
主动脉瓣疾病干预治疗后存在的种族差异仍未得到充分研究。我们在医疗保险数据库中,根据种族对接受外科主动脉瓣置换术(SAVR)和经导管主动脉瓣植入术(TAVI)的患者进行了分层。TAVI队列包括17973名患者(3.9%为黑人,1.0%为西班牙裔)。SAVR队列包括95078名患者(4.8%为黑人,1.3%为西班牙裔)。大多数合并症在黑人中更为常见。TAVI术后,未调整和调整后的数据显示,不同种族的30天死亡率无显著差异。TAVI术后再入院率或出院回家情况在种族上无显著差异。SAVR术后,黑人患者未经调整的30天和1年死亡率比白人和西班牙裔更差(30天死亡率,白人、黑人和西班牙裔分别为4.7%、6.2%和4.7%,p = 0.0001;1年死亡率分别为11.7%、16.1%和12.5%,p = 0.0001);然而,调整后,死亡率无差异。SAVR术后黑人患者的30天再入院率更高(白人、黑人和西班牙裔分别为20.1%、25.2%和21.7%,p = 0.0001),在对合并症进行调整后这一情况仍然存在。相对于根据人群患病率预测的比例,少数族裔在SAVR和TAVI中的占比均不足。总之,虽然与白人和西班牙裔相比,黑人在SAVR中的预后更差,但种族并未影响TAVI中的死亡率、再入院率或出院回家情况。与根据人群患病率预测的比例相比,黑人和西班牙裔的占比均不足。