Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
Department of Chemical Engineering, Chungbuk National University, Cheongju, Chungbuk 28644, Republic of Korea.
Bioresour Technol. 2018 Dec;269:544-556. doi: 10.1016/j.biortech.2018.08.120. Epub 2018 Aug 30.
Polyhydroxyalkanoates (PHAs) are the only polyesters that are completely synthesized biologically and possess features equivalent to petroleum-based plastics besides being biodegradable. PHA based materials may certainly prove helpful in addressing the concerns caused due to the indiscriminate use of synthetic plastics. However, the cost of producing these polymers on a large scale is still uneconomical. Various approaches have been developed to tackle this issue through usage of agro-industrial wastes, co-production of high market value products, polymer extraction using green solvents, etc. The advent of recombineering and CRISPR technologies has broadened the scope of constructing a microbe capable of synthesizing multiple products with economic feasibility. Quite a few high-market value chemicals are possible to synthesize along with the favorable accumulation of PHA. The present article attempts to review all PHA polymer co-production processes with other chemicals reported till date and discusses the opportunities for their large-scale operation in future.
聚羟基烷酸酯（PHA）是唯一完全生物合成且具有与石油基塑料相当的特性、可生物降解的聚酯。PHA 基材料肯定有助于解决由于滥用合成塑料而引起的问题。然而，大规模生产这些聚合物的成本仍然不经济。已经开发了各种方法来解决这个问题，包括使用农业工业废物、共同生产高市场价值产品、使用绿色溶剂提取聚合物等。重组和 CRISPR 技术的出现拓宽了构建能够以经济可行性合成多种产品的微生物的范围。有可能与 PHA 的有利积累一起合成许多高市场价值的化学品。本文试图综述迄今为止报道的所有与其他化学品共同生产 PHA 聚合物的工艺，并讨论未来大规模生产的机会。
