现在是时候将（2R，6R）-羟基去甲氯胺酮与其母体药物分开看待了。 - Suppr

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超能文献

Now is the time for (2R,6R)-hydroxynorketamine to be viewed independently from its parent drug.

作者信息

Chaki Shigeyuki, Yamaguchi Jun-Ichi

机构信息

Research Headquarters, Taisho Pharmaceutical Co., Ltd., 1-403 Yoshino-cho, Kita-ku, Saitama, Saitama 331-9530, Japan.

出版信息

Pharmacol Biochem Behav. 2018 Dec;175:24-26. doi: 10.1016/j.pbb.2018.09.005. Epub 2018 Sep 7.

DOI:10.1016/j.pbb.2018.09.005

PMID:30201385

Abstract

摘要

相似文献

Now is the time for (2R,6R)-hydroxynorketamine to be viewed independently from its parent drug.现在是时候将（2R，6R）-羟基去甲氯胺酮与其母体药物分开看待了。

Pharmacol Biochem Behav. 2018 Dec;175:24-26. doi: 10.1016/j.pbb.2018.09.005. Epub 2018 Sep 7.

Mouse, rat, and dog bioavailability and mouse oral antidepressant efficacy of ()-hydroxynorketamine.（）-羟基去甲氯胺在小鼠、大鼠和犬体内的生物利用度和抗抑郁疗效。

J Psychopharmacol. 2019 Jan;33(1):12-24. doi: 10.1177/0269881118812095. Epub 2018 Nov 29.

Lack of Antidepressant Effects of (2R,6R)-Hydroxynorketamine in a Rat Learned Helplessness Model: Comparison with (R)-Ketamine.（2R,6R）-羟基去甲氯胺酮在大鼠习得性无助模型中缺乏抗抑郁作用：与（R）-氯胺酮的比较。

Int J Neuropsychopharmacol. 2018 Jan 1;21(1):84-88. doi: 10.1093/ijnp/pyx108.

Lack of deuterium isotope effects in the antidepressant effects of (R)-ketamine in a chronic social defeat stress model.（R）-氯胺酮在慢性社会挫败应激模型中抗抑郁作用中无氘同位素效应。

Psychopharmacology (Berl). 2018 Nov;235(11):3177-3185. doi: 10.1007/s00213-018-5017-2. Epub 2018 Sep 13.

(R)-Ketamine exerts antidepressant actions partly via conversion to (2R,6R)-hydroxynorketamine, while causing adverse effects at sub-anaesthetic doses.(R)-氯胺酮通过转化为（2R,6R）-羟基去甲氯胺酮发挥抗抑郁作用，而在亚麻醉剂量下会引起不良反应。

Br J Pharmacol. 2019 Jul;176(14):2573-2592. doi: 10.1111/bph.14683. Epub 2019 May 13.

()-hydroxynorketamine exerts mGlu receptor-dependent antidepressant actions.()-羟基去甲氯胺通过 mGlu 受体发挥抗抑郁作用。

Proc Natl Acad Sci U S A. 2019 Mar 26;116(13):6441-6450. doi: 10.1073/pnas.1819540116. Epub 2019 Mar 13.

Lack of metabolism in (R)-ketamine's antidepressant actions in a chronic social defeat stress model.（R）-氯胺酮抗抑郁作用中代谢缺乏与慢性社会挫败应激模型。

Sci Rep. 2018 Mar 5;8(1):4007. doi: 10.1038/s41598-018-22449-9.

(R)-Ketamine Shows Greater Potency and Longer Lasting Antidepressant Effects Than Its Metabolite (2R,6R)-Hydroxynorketamine.（R）-氯胺酮比其代谢物（2R，6R）-羟基去甲氯胺酮具有更强的效力和更持久的抗抑郁作用。

Biol Psychiatry. 2017 Sep 1;82(5):e43-e44. doi: 10.1016/j.biopsych.2016.12.020. Epub 2016 Dec 23.

Activity-dependent brain-derived neurotrophic factor signaling is required for the antidepressant actions of (2,6)-hydroxynorketamine.（2,6）-羟基去甲氯胺的抗抑郁作用需要依赖活性的脑源性神经营养因子信号传导。

Proc Natl Acad Sci U S A. 2019 Jan 2;116(1):297-302. doi: 10.1073/pnas.1814709116. Epub 2018 Dec 17.

Sex-dependent metabolism of ketamine and ()-hydroxynorketamine in mice and humans.在小鼠和人体内，（）-羟基去甲氯胺酮和氯胺酮的性别依赖性代谢。

J Psychopharmacol. 2022 Feb;36(2):170-182. doi: 10.1177/02698811211064922. Epub 2021 Dec 31.

引用本文的文献

Hydroxynorketamine, but not ketamine, acts via α7 nicotinic acetylcholine receptor to control presynaptic function and gene expression.羟基去甲氯胺（羟考酮）而非氯胺酮通过α7 型烟碱型乙酰胆碱受体来控制突触前功能和基因表达。

Transl Psychiatry. 2024 Jan 22;14(1):47. doi: 10.1038/s41398-024-02744-y.

Pharmacological Mechanism of Ketamine in Suicidal Behavior Based on Animal Models of Aggressiveness and Impulsivity: A Narrative Review.基于攻击性和冲动性动物模型的氯胺酮在自杀行为中的药理机制：一篇叙述性综述

Pharmaceuticals (Basel). 2023 Apr 21;16(4):634. doi: 10.3390/ph16040634.

Molecular and cellular mechanisms underlying the antidepressant effects of ketamine enantiomers and its metabolites.氯胺酮对映异构体及其代谢物抗抑郁作用的分子和细胞机制。

Transl Psychiatry. 2019 Nov 7;9(1):280. doi: 10.1038/s41398-019-0624-1.

Rapid-acting antidepressant ketamine, its metabolites and other candidates: A historical overview and future perspective.快速作用抗抑郁药氯胺酮及其代谢物和其他候选药物：历史概述和未来展望。

Psychiatry Clin Neurosci. 2019 Oct;73(10):613-627. doi: 10.1111/pcn.12902. Epub 2019 Jul 11.

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