LAQV-REQUIMTE, Departamento de Química e Bioquímica, Faculdade de Ciências, Universidade do Porto, Porto, Portugal.
Ciências Químicas e das Biomoléculas, Escola Superior de Saúde, Politécnico do Porto, Porto, Portugal.
Antimicrob Agents Chemother. 2018 Oct 24;62(11). doi: 10.1128/AAC.00983-18. Print 2018 Nov.
The impact of pneumonia (PcP) on morbidity and mortality remains substantial for immunocompromised individuals, including those afflicted by HIV infection, organ transplantation, cancer, autoimmune diseases, or subject to chemotherapy or corticosteroid-based therapies. Previous work from our group has shown that repurposing antimalarial compounds for PcP holds promise for treatment of this opportunistic infection. Following our previous discovery of chloroquine analogues with dual-stage antimalarial action both and , we now report the potent action of these compounds on Identification of chloroquine analogues as anti-PcP leads is an unprecedented finding.
肺炎（PcP）对免疫功能低下个体（包括 HIV 感染者、器官移植受者、癌症患者、自身免疫性疾病患者或接受化疗或基于皮质类固醇的治疗者）的发病率和死亡率仍有重大影响。我们小组的先前工作表明，重新利用抗疟化合物治疗这种机会性感染具有很大的潜力。在我们先前发现具有双重阶段抗疟作用的氯喹类似物 和 之后，我们现在报告这些化合物对 的强烈作用。鉴定氯喹类似物作为抗 PcP 先导化合物是一项前所未有的发现。
