Cerebral autoregulation and activity after propofol for endotracheal intubation in preterm neonates.

BACKGROUND

Despite increasing use of propofol in neonates, observations on cerebral effects are limited.

AIM

To investigate cerebral autoregulation (CAR) and activity after propofol for endotracheal intubation in preterm neonates.

METHODS

Twenty-two neonates received propofol before intubation as part of a published dose-finding study. Mean arterial blood pressure (MABP), near-infrared spectroscopy-derived cerebral oxygenation (rScO), and amplitude-integrated electroencephalography (aEEG) were analyzed until 180 min after propofol. CAR was expressed as transfer function (TF) gain, indicating % change in rScO per 1 mmHg change in MABP. Values exceeding mean TF gain + 2 standard deviations (SD) defined impaired CAR.

RESULTS

After intubation with a median propofol dose of 1 (0.5-4.5) mg/kg, rScO remained stable during decreasing MABP. Mean (±SD) TF gain was 0.8 (±0.3)%/mmHg. Impaired CAR was identified in 1 and 5 patient(s) during drug-related hypotension and normal to raised MABP, respectively. Suppressed aEEG was observed up to 60 min after propofol.

CONCLUSIONS

Drug-related hypotension and decreased cerebral activity after intubation with low propofol doses in preterm neonates were observed, without evidence of cerebral ischemic hypoxia. CAR remained intact during drug-related hypotension in 95.5% of patients. Cerebral monitoring including CAR clarifies the cerebral impact of MABP fluctuations.