疑似或已知新生儿败血症和 5 岁时神经发育迟缓。
Suspected or known neonatal sepsis and neurodevelopmental delay by 5 years.
机构信息
Department of Pediatrics, Walter Reed National Military Medical Center, Bethesda, MD, USA.
Department of Pediatrics, Uniformed Services University of the Health Sciences, Bethesda, MD, USA.
出版信息
J Perinatol. 2018 Nov;38(11):1573-1580. doi: 10.1038/s41372-018-0217-5. Epub 2018 Sep 10.
OBJECTIVE
Evaluate impact of known and suspected neonatal sepsis in the term and preterm infant on neurodevelopmental delay by 5 years.
STUDY DESIGN
Included infants were born in 2009-2010 and followed for 5 years. Diagnostic codes and at least 5 days of antibiotic use identified suspected sepsis. Laboratory results confirmed known sepsis. Diagnostic codes stratified developmental delay by sub-type. Logistic regression analysis determined odds of developmental delay for sepsis and suspected sepsis.
RESULTS
Of 65,938 included infants, 190 had sepsis and 3449 had suspected sepsis. After adjustment for known developmental risk factors, sepsis and suspected sepsis were associated with increased risk for any developmental delay, (1.48 (1.05-2.09) and 1.09 (1.01-1.18)), respectively, and multiple developmental delay sub-types.
CONCLUSION
Neonatal sepsis and suspected sepsis are associated with neurodevelopmental delay by 5 years of age.
目的
评估足月和早产儿中已知和疑似新生儿败血症对 5 岁时神经发育迟缓的影响。
研究设计
纳入的婴儿于 2009-2010 年出生，并随访 5 年。诊断代码和至少 5 天的抗生素使用确定疑似败血症。实验室结果证实了已知的败血症。诊断代码按亚型对发育迟缓进行分层。逻辑回归分析确定败血症和疑似败血症与发育迟缓的几率。
结果
在纳入的 65938 名婴儿中，有 190 名患有败血症，3449 名患有疑似败血症。在调整已知的发育风险因素后，败血症和疑似败血症与任何发育迟缓（1.48（1.05-2.09）和 1.09（1.01-1.18））以及多种发育迟缓亚型的风险增加相关。
结论
新生儿败血症和疑似败血症与 5 岁时的神经发育迟缓有关。
Zotero 插件