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1型人类嗜T淋巴细胞病毒脊髓病患者的帕金森综合征

Parkinsonism in a Patient with Human T-lymphotropic Virus 1 Myelopathy.

作者信息

Afzal Hasnain, Kadakia Satish, Lev Steven

机构信息

Resident Physician Psychiatry, Nassau University Medical Center, East Meadow, USA.

Chairman Department of Neurology, Nassau University Medical Center, East Meadow, USA.

出版信息

Cureus. 2018 Jul 7;10(7):e2940. doi: 10.7759/cureus.2940.

DOI:10.7759/cureus.2940
PMID:30202671
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6128598/
Abstract

Human T-lymphotropic virus 1 (HTLV-1) infection is commonly associated with neurological conditions like chronic progressive myelopathy and tropical spastic paraparesis (TSP) but rarely also reported with polymyositis, multiple sclerosis, and parkinsonism. It is important to recognize that HTLV-1 infection increases the risk of these neurological conditions. We present a case of 71-year-old female with HTLV-1 associated chronic progressive myelopathy with parkinsonism which signifies that it is under-recognized and not frequently reported due to lack of expert neurological assessment in these chronically debilitated patients.

摘要

人类嗜T淋巴细胞病毒1型(HTLV-1)感染通常与慢性进行性脊髓病和热带痉挛性截瘫(TSP)等神经系统疾病相关,但也很少有与多发性肌炎、多发性硬化症和帕金森综合征相关的报道。认识到HTLV-1感染会增加这些神经系统疾病的风险很重要。我们报告一例71岁女性,患有与HTLV-1相关的慢性进行性脊髓病伴帕金森综合征,这表明由于这些长期衰弱患者缺乏专业的神经学评估,该病未得到充分认识且报道不频繁。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1e2/6128598/4a7f6a0fa1f7/cureus-0010-00000002940-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1e2/6128598/4a7f6a0fa1f7/cureus-0010-00000002940-i01.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c1e2/6128598/4a7f6a0fa1f7/cureus-0010-00000002940-i01.jpg

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本文引用的文献

1
Human T-cell lymphotropic virus (HTLV)-associated encephalopathy: an under-recognised cause of acute encephalitis? Case series and literature review.人类 T 细胞嗜淋巴细胞病毒(HTLV)相关脑病:急性脑炎的一个被低估的病因?病例系列和文献复习。
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帕金森病的MDS临床诊断标准。
Mov Disord. 2015 Oct;30(12):1591-601. doi: 10.1002/mds.26424.
4
Mother-to-Child Transmission of Human T-Cell Lymphotropic Viruses-1/2: What We Know, and What Are the Gaps in Understanding and Preventing This Route of Infection.人类嗜T细胞病毒1型/2型的母婴传播:我们所了解的情况,以及在理解和预防这种感染途径方面存在的差距。
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Parkinson disease: an update.帕金森病:最新进展。
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Parkinson's disease.帕金森病。
Subcell Biochem. 2012;65:389-455. doi: 10.1007/978-94-007-5416-4_16.
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Higher iron in the red nucleus marks Parkinson's dyskinesia.红核中铁含量升高提示帕金森病异动症。
Neurobiol Aging. 2013 May;34(5):1497-503. doi: 10.1016/j.neurobiolaging.2012.10.025. Epub 2012 Nov 21.
8
Epidemiology, treatment, and prevention of human T-cell leukemia virus type 1-associated diseases.人类 T 细胞白血病病毒 1 型相关疾病的流行病学、治疗和预防。
Clin Microbiol Rev. 2010 Jul;23(3):577-89. doi: 10.1128/CMR.00063-09.
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Viral parkinsonism.病毒性帕金森综合征
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10
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