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早期精神病中的睡眠障碍:发生率、严重程度及与临床症状的关系。

Sleep Disorders in Early Psychosis: Incidence, Severity, and Association With Clinical Symptoms.

机构信息

Department of Psychiatry, University of Oxford, Warneford Hospital, Oxford, UK.

Oxford Health NHS Foundation Trust, Oxford, UK.

出版信息

Schizophr Bull. 2019 Mar 7;45(2):287-295. doi: 10.1093/schbul/sby129.

Abstract

Sleep disturbance is known to be associated with psychosis, but sleep disorders (eg, insomnia, nightmare disorder, sleep apnea) have rarely been investigated. We aimed to provide the first detailed assessment of sleep disorders and their correlates in patients with early psychosis. Sixty outpatients aged between 18 and 30 with nonaffective psychosis were assessed for sleep disorder presence, severity, and treatment using a structured diagnostic interview, sleep diaries, and actigraphy. Psychotic experiences, mood, and psychological wellbeing were also measured. Forty-eight patients (80%) had at least one sleep disorder, with insomnia and nightmare disorder being the most common. Comorbidity of sleep disorders within this group was high, with an average of 3.3 sleep disorders per patient. Over half of the sleep disorders had been discussed with a clinician but almost three-quarters had received no treatment. Treatment according to clinical guidelines was rare, occurring in only 8% of cases (n = 13). Sleep disorders were significantly associated with increased psychotic experiences, depression, anxiety, fatigue, and lower quality of life. Sleep disorders are very common in patients with psychosis, may have wide-ranging negative effects, and merit routine assessment and treatment in psychiatric practice.

摘要

睡眠障碍与精神病有关,但睡眠障碍(如失眠、噩梦障碍、睡眠呼吸暂停)很少被研究。我们旨在首次详细评估早期精神病患者的睡眠障碍及其相关性。使用结构化诊断访谈、睡眠日记和活动记录仪,对 60 名年龄在 18 至 30 岁之间的非情感性精神病门诊患者进行睡眠障碍的存在、严重程度和治疗情况评估。还测量了精神病体验、情绪和心理健康。48 名患者(80%)至少有一种睡眠障碍,其中失眠和噩梦障碍最为常见。该组患者的睡眠障碍共病率很高,平均每位患者有 3.3 种睡眠障碍。超过一半的睡眠障碍已经与临床医生讨论过,但几乎四分之三的患者没有接受治疗。根据临床指南进行的治疗非常罕见,仅发生在 8%的病例中(n=13)。睡眠障碍与增加的精神病体验、抑郁、焦虑、疲劳和较低的生活质量显著相关。睡眠障碍在精神病患者中非常常见,可能会产生广泛的负面影响,因此在精神科实践中值得进行常规评估和治疗。

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