Daus W, Zimmer K P, Möller P
Klin Monbl Augenheilkd. 1986 Jun;188(6):604-9. doi: 10.1055/s-2008-1050727.
The authors report on a baby born on August 25, 1984 with a birthweight of 1100 g. Her parents used drugs intravenously and her mother had anti-HTLV III antibody. In the clinical course an immune deficiency syndrome with pathologic reduction of T4:T8 (T-helper: T-suppressor cells) was apparent. The child had no anti-HTLV III antibody, but exposition, typical clinical course and immunological data led to the diagnosis Acquired Immune Deficiency Syndrome (AIDS). In the 9th month bilateral progressive retinitis developed; it was thought to have been induced by cytomegalovirus. Complement-fixation antibody titer for cytomegalovirus was negative, but the virus was found in the urine. In the 12th month the baby died of cardiac arrhythmia caused by cytomegalic myocarditis. Macroscopic and light-microscopic illustrations of the inflammatory changes in both eyes are presented; in the retina there were large multinucleated cells which were visible macroscopically.
作者报告了一名于1984年8月25日出生的婴儿，出生体重为1100克。其父母有静脉注射毒品史，母亲有抗人类嗜T淋巴细胞病毒III型（HTLV III）抗体。在临床病程中，出现了免疫缺陷综合征，表现为T4:T8（辅助性T细胞:抑制性T细胞）比例病理性降低。该儿童没有抗HTLV III抗体，但鉴于其接触史、典型的临床病程和免疫学数据，诊断为获得性免疫缺陷综合征（艾滋病）。在第9个月时，出现双侧进行性视网膜炎；据认为是由巨细胞病毒引起的。巨细胞病毒补体结合抗体滴度为阴性，但在尿液中发现了该病毒。在第12个月时，婴儿死于由巨细胞性心肌炎引起的心律失常。文中展示了双眼炎症变化的大体和光学显微镜图像；视网膜中有肉眼可见的大型多核细胞。
