Borsodi A, Toth G
Neuropeptides. 1986 Jul;8(1):51-4. doi: 10.1016/0143-4179(86)90064-8.
The role of microtubules in opioid receptor binding was studied by using microtubule assembly inhibitors. Preincubation of rat cerebrum membranes with podophyllotoxin or colchicine provoked a marked increase in the number of binding sites as judged by [3H]-naloxone, [3H]-morphine and [3H]-D-Ala2-Leu5-enkephalin binding experiments. These results indicate microtubule involvement in regulation of opioid receptor expression.
通过使用微管组装抑制剂研究了微管在阿片受体结合中的作用。用鬼臼毒素或秋水仙碱对大鼠大脑膜进行预孵育后，通过[3H] -纳洛酮、[3H] -吗啡和[3H] -D -丙氨酸2 -亮氨酸5 -脑啡肽结合实验判断，结合位点的数量显著增加。这些结果表明微管参与了阿片受体表达的调节。
