Department of Biochemistry & Biophysics, University of California, San Francisco, San Francisco, CA, USA.
Dev Cell. 2018 Sep 10;46(5):529-530. doi: 10.1016/j.devcel.2018.08.020.
A recent study in Nature Cell Biology (Almuedo-Castillo et al., 2018) describes a mechanism for tissue scaling in zebrafish embryos. The authors show that a fixed relative amount of the diffusible Nodal inhibitor Lefty produces an extended gradient in larger embryos, ensuring proportionally scaled germ layers, irrespective of embryo size.
最近发表在《自然细胞生物学》(Almuedo-Castillo 等人,2018 年)上的一项研究描述了斑马鱼胚胎组织缩放的一种机制。作者表明,扩散性 Nodal 抑制剂 Lefty 的固定相对量在较大的胚胎中产生了一个延伸的梯度,从而确保了比例相称的胚层,而与胚胎大小无关。