Zsilla G, Földi P, Held G, Székely A M, Knoll J
Pol J Pharmacol Pharm. 1986 Jan-Feb;38(1):57-67.
The action of clorgyline and (-)deprenyl on the dynamics of dopaminergic and serotonergic transmission in the rat brain was compared. It was found, that daily administration of 0.25 mg/kg sc clorgyline, a specific MAO A inhibitor, reduced the turnover rate of both dopamine and serotonin after two weeks of injections. The treatment for two or four weeks with 0.25 mg/kg sc (-)deprenyl, a specific MAO B inhibitor, enhanced the turnover rate of dopamine and the fractional rate constant of dopamine efflux, reflecting an increased utilization rate of this amine in the striatum. Beside the augmentation of the dopamine turnover rate, the dopaminergic tone was also elevated by the reduction of the dopamine uptake in the striatum. Two week injections with the same dose of (-)deprenyl did not change the dynamics of serotonergic transmission.
比较了氯吉兰和（-）司来吉兰对大鼠脑内多巴胺能和5-羟色胺能传递动力学的作用。结果发现，每天皮下注射0.25mg/kg的氯吉兰（一种特异性单胺氧化酶A抑制剂），在注射两周后可降低多巴胺和5-羟色胺的更新率。用0.25mg/kg皮下注射（-）司来吉兰（一种特异性单胺氧化酶B抑制剂）进行两周或四周治疗，可提高多巴胺的更新率和多巴胺流出的分数速率常数，这反映出纹状体内该胺的利用率增加。除了多巴胺更新率增加外，纹状体内多巴胺摄取减少也使多巴胺能张力升高。用相同剂量的（-）司来吉兰注射两周并未改变5-羟色胺能传递的动力学。
