姜黄素对肾毒性药物的保护作用。
Protective Effects of Curcumin Against Nephrotoxic Agents.
作者信息
Farkhondeh Tahereh, Samarghandian Saeed, Azimi-Nezhad Mohsen, Shahri Ali M P
机构信息
Cardiovascular Diseases Research Center, Birjand University of Medical Sciences, Birjand, Iran.
Department of Basic Medical Sciences, Neyshabur University of Medical Sciences, Neyshabur, Iran.
出版信息
Cardiovasc Hematol Disord Drug Targets. 2019;19(3):176-182. doi: 10.2174/1871529X18666180905160830.
BACKGROUND
Curcumin is the one of the main phenolic ingredients in curcuma species rhizome. Curcuma species have traditionally been used for the treatment of diabetes, cardiovascular, and renal diseases.
METHODS
The present study was designed to review the scientific literature on the protective effects of curcumin against nephrotoxic agents.
RESULTS
Studies have shown the protective effects of curcumin against nephrotoxic agents such as gallic acid, glucose, tartrazine, streptozotocin, lead, cadmium, fluoride, maleate, malathion, nicotine, cisplatin, gentamicin, and methotrexate. However, further investigations are needed to determine the efficacy of curcumin as an antidote agent due to the lack of clinical trial studies. Therefore, it is recommended to conduct clinical trials in humans to confirm these effects.
CONCLUSION
The current review indicated that curcumin may be effective against nephrotoxicity by modulating oxidative stress and inflammatory responses.
背景
姜黄素是姜黄属植物根茎中的主要酚类成分之一。姜黄属植物传统上用于治疗糖尿病、心血管疾病和肾脏疾病。
方法
本研究旨在综述关于姜黄素对肾毒性药物保护作用的科学文献。
结果
研究表明姜黄素对诸如没食子酸、葡萄糖、酒石黄、链脲佐菌素、铅、镉、氟化物、马来酸盐、马拉硫磷、尼古丁、顺铂、庆大霉素和甲氨蝶呤等肾毒性药物具有保护作用。然而，由于缺乏临床试验研究，需要进一步研究以确定姜黄素作为解毒剂的疗效。因此，建议在人体中进行临床试验以证实这些作用。
结论
当前综述表明，姜黄素可能通过调节氧化应激和炎症反应对肾毒性有效。
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