白三烯B4在人淋巴细胞培养物中刺激白细胞介素2和γ干扰素的产生。
Stimulation of interleukin 2 and interferon gamma production by leukotriene B4 in human lymphocyte cultures.
作者信息
Rola-Pleszczynski M, Chavaillaz P A, Lemaire I
出版信息
Prostaglandins Leukot Med. 1986 Aug;23(2-3):207-10. doi: 10.1016/0262-1746(86)90187-3.
PMID:3020587
Abstract
Interleukin 2 (IL-2) and interferon-gamma (IFN) production by human lymphocytes was significantly enhanced in the presence of leukotriene B4 (LTB4) and indomethacin. Depletion of the T8+ suppressor cell subset of human T cells resulted in enhanced lymphokine production and further augmentation by LTB4. These findings suggest that LTB4 can regulate immune responses through its modulation of lymphokine production.
摘要
在白三烯B4（LTB4）和吲哚美辛存在的情况下，人淋巴细胞产生白细胞介素2（IL-2）和γ干扰素（IFN）的能力显著增强。人T细胞中T8 +抑制细胞亚群的耗竭导致淋巴因子产生增加，并且LTB4进一步增强了这种增加。这些发现表明，LTB4可以通过调节淋巴因子的产生来调节免疫反应。
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