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Effects of liver disease and of aging on the disposition and elimination of sedatives.肝脏疾病及衰老对镇静剂处置与消除的影响。
Trans Am Clin Climatol Assoc. 1978;89:91-9.
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The effects of liver disease and aging on the disposition of diazepam, chlordiazepoxide, oxazepam and lorazepam in man.肝脏疾病和衰老对人地西泮、氯氮䓬、奥沙西泮和劳拉西泮处置的影响。
Acta Psychiatr Scand Suppl. 1978(274):56-74. doi: 10.1111/j.1600-0447.1978.tb02388.x.
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Disposition and elimination of minor tranquilizers in the aged and in patients with liver disease.老年患者及肝病患者体内小剂量镇静剂的处置与消除
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Effects of aging and liver disease on disposition of lorazepam.
Clin Pharmacol Ther. 1978 Oct;24(4):411-9. doi: 10.1002/cpt1978244411.
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[Therapeutic notes: benzodiazepines].[治疗笔记：苯二氮䓬类药物]
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Clinical pharmacokinetics of oxazepam and lorazepam.奥沙西泮和劳拉西泮的临床药代动力学
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Differential effects of oral contraceptive steroids on the metabolism of benzodiazepines.口服避孕药类固醇对苯二氮䓬类药物代谢的不同影响。
Hepatology. 1983 Mar-Apr;3(2):248-53. doi: 10.1002/hep.1840030219.
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The effect of parenchymal liver disease on the disposition and elimination of sedatives and analgesics.实质性肝脏疾病对镇静剂和镇痛药的处置及消除的影响。
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The use of benzodiazepines in clinical practice.苯二氮䓬类药物在临床实践中的应用。
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本文引用的文献

1
VARIATION IN THE ACTIVITY OF LIVER MICROSOMAL DRUG-METABOLIZING ENZYMES IN RATS IN RELATION TO THE AGE.大鼠肝脏微粒体药物代谢酶活性随年龄的变化
Biochem Pharmacol. 1964 Jul;13:1037-51. doi: 10.1016/0006-2952(64)90100-5.
2
Metabolism of drugs in subjects with Laennec's cirrhosis.Laennec 肝硬化患者的药物代谢
Med Exp Int J Exp Med. 1959;1:290-2. doi: 10.1159/000134806.
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[Pharmacokinetics of meprobamate in chronic liver diseases and drug addiction].[眠尔通在慢性肝病和药物成瘾中的药代动力学]
Klin Wochenschr. 1969 Jan 15;47(2):78-80. doi: 10.1007/BF01745770.
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Plasma disappearance and cerebral effects of chlorpromazine in cirrhosis.肝硬化患者中氯丙嗪的血浆清除率及对脑部的影响
Clin Sci. 1972 Aug;43(2):143-51. doi: 10.1042/cs0430143.
5
Clinical depression of the central nervous system due to diazepam and chlordiazepoxide in relation to cigarette smoking and age.地西泮和氯氮䓬所致中枢神经系统临床抑郁与吸烟及年龄的关系
N Engl J Med. 1973 Feb 8;288(6):277-80. doi: 10.1056/NEJM197302082880602.
6
Changes in hepatic circulation at rest, during and after exercise in young males with infectious hepatitis compared with controls.
Acta Med Scand. 1974 Oct;196(4):315-25. doi: 10.1111/j.0954-6820.1974.tb01017.x.
7
The effects of age and liver disease on the disposition and elimination of diazepam in adult man.年龄和肝脏疾病对成年男性体内地西泮处置与消除的影响。
J Clin Invest. 1975 Feb;55(2):347-59. doi: 10.1172/JCI107938.
8
Intravenous administration of diazepam in patients with chronic liver disease.慢性肝病患者静脉注射地西泮
Gut. 1976 Dec;17(12):975-83. doi: 10.1136/gut.17.12.975.
9
Comparison of the pharmacokinetics of diazepam after single and subchronic doses.单次和亚慢性剂量后地西泮的药代动力学比较。
Eur J Clin Pharmacol. 1976 Jun 15;10(2):121-6. doi: 10.1007/BF00609470.
10
Benzodiazepine receptor: demonstration in the central nervous system.苯二氮䓬受体：在中枢神经系统中的显示
Science. 1977 Nov 25;198(4319):849-51. doi: 10.1126/science.918669.

Effects of liver disease and of aging on the disposition and elimination of sedatives.

作者信息

Schenker S

出版信息

Trans Am Clin Climatol Assoc. 1978;89:91-9.

PMID:30206
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2279428/
Abstract
摘要