Rayevsky V V, Rokyta R
Physiol Bohemoslov. 1986;35(4):340-3.
Monoamines, which participate in synaptic transmission as transmitters, also accomplish the modulation of neuronal activity. The role of serotonin (5-hydroxytryptamine--5-HT) was investigated in 8 to 14-day-old kittens by means of iontophoretic application onto neurones of the somatosensory cerebral cortex. The most typical response was the inhibition of neuronal activity. Another type of reaction was generated by inhibitory interneurones. After the microiontophoretic application of 5-HT, the tonic response of cortical neurones to the stimulation of the sciatic nerve changed into a phasic response. It is being suggested that the application of 5-HT to cortical neurones increases the excitability of inhibitory neurones. Hence, the serotoninergic regulation of neuronal activity in the somatosensory cortex may be operational from the 11th to the 12th day of postnatal life in cats.
作为神经递质参与突触传递的单胺类物质，也实现对神经元活动的调节。通过离子电泳法将血清素（5-羟色胺——5-HT）施加到8至14日龄小猫的体感大脑皮质神经元上，对血清素的作用进行了研究。最典型的反应是神经元活动受到抑制。另一种类型的反应是由抑制性中间神经元产生的。在对皮质神经元进行微量离子电泳施加5-HT后，皮质神经元对坐骨神经刺激的紧张性反应转变为相位性反应。有人提出，将5-HT应用于皮质神经元会增加抑制性神经元的兴奋性。因此，血清素能对猫体感皮质中神经元活动的调节可能在出生后第11至12天起作用。
