Chuvaev A V, Mal'kova D A
Vopr Pitan. 1977 Jan-Feb(1):54-7.
Tests staged on normal and hypophysectomized rats demonstrated thyroxin to potentiate the general toxic effect of ergocalciferol, with final death of the animals. At the same time, the blood calcium content in animals receiving thyroxin decreases under the effect of the latter. Hydrocortisone, while producing no effect on the high calcium content in the blood of the animals receiving ergocalciferol, attenuates the general toxic action of the latter. These data point to the possibility of dissociating the general toxic action of ergocalciferol and its influence on the blood calcium level, which disproves the existing notion on the correlation between general toxic action of ergocalciferol and hypercalcemia produced by it. Thyroxin and hydrocortisone do not have any effect on the nature of the action exerted by high doses of vitamin A.
在正常大鼠和垂体切除大鼠身上进行的试验表明，甲状腺素会增强麦角钙化醇的一般毒性作用，最终导致动物死亡。与此同时，接受甲状腺素的动物血液中的钙含量在甲状腺素的作用下会降低。氢化可的松虽然对接受麦角钙化醇的动物血液中的高钙含量没有影响，但会减弱后者的一般毒性作用。这些数据表明，有可能将麦角钙化醇的一般毒性作用与其对血钙水平的影响区分开来，这推翻了关于麦角钙化醇的一般毒性作用与其所导致的高钙血症之间相关性的现有观念。甲状腺素和氢化可的松对高剂量维生素A所产生的作用性质没有任何影响。
