Department of Neonatology, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.
Department of Preventive and Social Medicine, Jawaharlal Institute of Postgraduate Medical Education and Research (JIPMER), Puducherry, 605006, India.
J Perinatol. 2018 Nov;38(11):1512-1517. doi: 10.1038/s41372-018-0223-7. Epub 2018 Sep 11.
To evaluate whether a strategy of restricted fluid intake in the first 4 days reduces mortality and morbidity among term neonates with moderate to severe hypoxic ischemic encephalopathy (HIE) treated with therapeutic hypothermia.
Eighty neonates with HIE were randomized between January 2016 and February 2018 to receive normal fluid intake (n = 40) or restricted fluid intake (two-third of normal intake; n = 40) in the first 4 days of life. The primary outcome was a composite of death or major neurodevelopmental disability at 6 months of age.
The primary outcome occurred in 10 infants (26%) in the fluid-restricted group and 3 infants (8%) in the normal fluid intake group, but the difference was not statistically significant (p = 0.065). Five infants in the fluid-restricted group had hypoglycemia (p = 0.055).
Restricted fluid intake did not reduce the composite outcome of death or neurodevelopmental disability and was associated with a trend toward more hypoglycemia.
评估在接受治疗性低温治疗的中度至重度缺氧缺血性脑病（HIE）足月新生儿中，前 4 天限制液体摄入的策略是否能降低死亡率和发病率。
2016 年 1 月至 2018 年 2 月，80 名患有 HIE 的新生儿被随机分为两组，分别在前 4 天接受正常液体摄入（n=40）或限制液体摄入（正常摄入的三分之二；n=40）。主要结局是 6 个月时死亡或主要神经发育障碍的复合结局。
在限制液体摄入组的 10 名婴儿（26%）和正常液体摄入组的 3 名婴儿（8%）中出现了主要结局，但差异无统计学意义（p=0.065）。限制液体摄入组的 5 名婴儿出现低血糖（p=0.055）。
限制液体摄入并未降低死亡或神经发育障碍的复合结局，并且与低血糖的趋势增加相关。
