基底神经节与海马体之间的关系：黑质和苍白球的作用。

Relations between basal ganglia and hippocampus: action of substantia nigra and pallidum.

作者信息

Sabatino M, La Grutta V, Ferraro G, La Grutta G

出版信息

Rev Electroencephalogr Neurophysiol Clin. 1986 Jul;16(2):179-90. doi: 10.1016/s0370-4475(86)80010-7.

PMID:3020650

Abstract

Several interrelationships exist between basal ganglia and hippocampus. The ventral striatum appears to be involved in the control of the dopaminergic nigro-striatal pathway. The caudate, in turn, seems to influence the hippocampal theta rhythm and to inhibit hippocampal spikes. In the present work the role played by globus pallidus pars interna and substantia nigra pars compacta on hippocampal bioelectrical activity is studied. Injection of sodium penicillin i.v. produces steady interictal spikes in the hippocampus. Substantia nigra stimulation induces regular theta rhythm and inhibits the spikes. Pallidal stimulation, on the contrary, appears to strongly enhance epileptiform activity, proceeding to generalised seizure activity. The results are discussed in the light of a putative feedback loop from basal ganglia to hippocampus, probably underlying co-participation of the two subcortical structures in the control of motor behaviour.

摘要

基底神经节与海马体之间存在多种相互关系。腹侧纹状体似乎参与多巴胺能黑质 - 纹状体通路的控制。反过来，尾状核似乎会影响海马体的θ节律并抑制海马体尖峰。在本研究中，探讨了苍白球内侧部和黑质致密部对海马体生物电活动的作用。静脉注射青霉素钠会在海马体中产生稳定的发作间期尖峰。刺激黑质会诱发规则的θ节律并抑制尖峰。相反，刺激苍白球似乎会强烈增强癫痫样活动，进而发展为全身性癫痫发作活动。根据从基底神经节到海马体的假定反馈回路对结果进行了讨论，这可能是这两个皮质下结构共同参与运动行为控制的基础。