Nagelhout J J, Ferdinand R T, Beuthin F C
Res Commun Chem Pathol Pharmacol. 1986 Aug;53(2):261-4.
Chronic exposure to anesthetic concentrations of halothane during the prenatal and early postnatal periods inhibits the incorporation of the leucine into myelin subcellular fractions in the rat. The enzyme 2',3' - cyclic nucleotide 3' - phosphodiesterase (CNPase) has been widely used as a myelin marker. To determine the effect of halothane on the developmental profile of CNPase, two groups of pregnant Sprague Dawley rats were exposed to 500 p.p.m. or 250 p.p.m. halothane, eight hours per day, five days per week from the third day after conception through postnatal day ten. Control animals were exposed to air alone. CNPase activity was significantly decreased by 500 p.p.m. halothane (34%) and by 250 p.p.m. halothane (29%) at postnatal day 17. Brain and body weights in both halothane treated groups were also less than control animals throughout the measurement period. The data indicates that chronic pre- and postnatal halothane exposure at low levels delays myelination in the rat.
在产前和产后早期长期接触麻醉浓度的氟烷会抑制大鼠体内亮氨酸掺入髓磷脂亚细胞组分。2',3'-环核苷酸3'-磷酸二酯酶（CNPase）已被广泛用作髓磷脂标记物。为了确定氟烷对CNPase发育情况的影响，两组怀孕的斯普拉格-道利大鼠从受孕后第三天到出生后第十天，每天暴露于500 ppm或250 ppm的氟烷中8小时，每周5天。对照动物仅暴露于空气中。在出生后第17天，500 ppm氟烷使CNPase活性显著降低（34%），250 ppm氟烷使其降低（29%）。在整个测量期间，两个氟烷处理组的脑重和体重也均低于对照动物。数据表明，产前和产后长期低水平接触氟烷会延迟大鼠的髓鞘形成。
