通过计量学介导的固态手性拆分：用 ZnCl 结晶乙琥胺。

Solid-state chiral resolution mediated by stoichiometry: crystallizing etiracetam with ZnCl.

机构信息

Molecular Crystal Engineering Laboratory, Dipartimento di Chimica "G. Ciamician", Università di Bologna, Via F. Selmi 2, 40126 Bologna, Italy.

出版信息

Chem Commun (Camb). 2018 Sep 25;54(77):10890-10892. doi: 10.1039/c8cc06199h.

DOI:10.1039/c8cc06199h

PMID:30206604

Abstract

Chiral resolution of racemic etiracetam was achieved via co-crystallization with ZnCl2. Depending on the amount of ZnCl2 either a stable racemic compound or a stable conglomerate can be obtained. Excess ZnCl2 triggers the quantitative conversion of the racemate into the conglomerate solid; this unprecedented behaviour was investigated through a racetam/ZnCl2/solvent phase diagram.

摘要

消旋乙拉醋胺通过与 ZnCl2 共结晶实现对映体拆分。根据 ZnCl2 的用量，可以得到稳定的外消旋化合物或稳定的内消旋化合物。过量的 ZnCl2 会促使外消旋体定量转化为内消旋固体；通过 racetam/ZnCl2/溶剂相图研究了这种前所未有的行为。