一系列氯化锌（II）苯甲酰胺配合物的晶体结构与氢键分析
Crystal structures and hydrogen-bonding analysis of a series of benzamide complexes of zinc(II) chloride.
作者信息
Tinapple Elizabeth, Farrar Sam, Johnston Dean H
机构信息
Department of Chemistry, Otterbein University, Westerville, OH 43081, USA.
出版信息
Acta Crystallogr E Crystallogr Commun. 2021 Aug 17;77(Pt 9):880-886. doi: 10.1107/S2056989021008264. eCollection 2021 Sep 1.
Ionic co-crystals are co-crystals between organic mol-ecules and inorganic salt coformers. Co-crystals of pharmaceuticals are of inter-est to help control polymorph formation and potentially improve stability and other physical properties. We describe the preparation, crystal structures, and hydrogen bonding of five different 2:1 benzamide or tolu-amide/zinc(II) chloride co-crystal salts, namely, bis-(benzamide-κ)di-chlorido-zinc(II), [ZnCl(CHNO)], di-chlor-ido-bis-(2-methyl-benzamide-κ)zinc(II), [ZnCl(CHNO)], di-chlorido-bis-(3-methyl-benzamide-κ)zinc(II), [ZnCl(CHNO)], di-chlorido-bis-(4-methyl-benzamide-κ)zinc(II), [ZnCl(CHNO)], and di-chlorido-bis-(4-hy-droxy-benzamide-κ)zinc(II), [ZnCl(CHNO)]. All of the complexes contain hydrogen bonds between the amide N-H group and the amide carbonyl oxygen atoms or the chlorine atoms, forming extended networks.
离子共晶体是有机分子与无机盐共形成物之间的共晶体。药物共晶体有助于控制多晶型的形成，并有可能提高稳定性和其他物理性质，因而受到关注。我们描述了五种不同的2:1苯甲酰胺或甲苯酰胺/氯化锌（II）共晶体盐的制备、晶体结构和氢键，即双（苯甲酰胺-κ）二氯锌（II），[ZnCl(CHNO)]、二氯双（2-甲基苯甲酰胺-κ）锌（II），[ZnCl(CHNO)]、二氯双（3-甲基苯甲酰胺-κ）锌（II），[ZnCl(CHNO)]、二氯双（4-甲基苯甲酰胺-κ）锌（II），[ZnCl(CHNO)]，以及二氯双（4-羟基苯甲酰胺-κ）锌（II），[ZnCl(CHNO)]。所有配合物在酰胺N-H基团与酰胺羰基氧原子或氯原子之间均含有氢键，形成了扩展网络。
Zotero 插件