School of Environmental Science and Engineering, Shandong University, China -America CRC for Environment & Health, Shandong Province, 27# Shanda South Road, Jinan 250100, China.
Department of Chemistry and Chemical Engineering, Qilu Normal University, Jinan 250013, China.
Mini Rev Med Chem. 2020;20(6):432-443. doi: 10.2174/1389557518666180912105345.
Bisphenol A (BPA) is a widely spreading environmental endocrine disruptor . Its characteristics, including small doses and frequent contact, make it easy to enter human body through drinking water, food, air and other pathways, leading to tumors, infertility, and liver damage. The present review summarizes the underlying mechanism of oxidative stress and its related effects induced by BPA in the liver. The progress of the mechanism for oxidative stress induced by BPA is summarized, including mitochondrial dysfunction, lipid peroxidation and inflammation reaction, liver dyslipidemia, apoptosis, and cell death mechanism. In the future, it is necessary to elucidate the molecular mechanisms and timing of oxidative stress to clarify the effects on different exposures to different genders and growth stages. Besides, studying the toxic effects on BPA surrogates, BPA metabolites and BPA combined with other pollutants in the environment is beneficial to clarify the environmental and human health effects of BPA and provide technical reference for the development of practical control measures.
双酚 A（BPA）是一种广泛存在的环境内分泌干扰物。其特点是剂量小、接触频繁，容易通过饮用水、食物、空气等途径进入人体，导致肿瘤、不孕和肝损伤。本综述总结了 BPA 在肝脏中诱导氧化应激的潜在机制及其相关作用。总结了 BPA 诱导氧化应激的机制进展，包括线粒体功能障碍、脂质过氧化和炎症反应、肝脂代谢紊乱、细胞凋亡和细胞死亡机制。未来有必要阐明氧化应激的分子机制和时程，以明确其对不同性别和生长阶段不同暴露的影响。此外，研究 BPA 替代物、BPA 代谢物和 BPA 与环境中其他污染物联合的毒性作用，有利于阐明 BPA 的环境和人类健康影响，为制定实用的控制措施提供技术参考。
