Li Junyan, Niu Xiaohong, Li JianBo, Wang Qingzhong
Department of Endocrinology and Metabolism, The First Affiliated Hospital of Nanjing Medical University, Nanjing, China.
Changzhi Medical College Affiliated Heji Hospital, Endocrinology and Metabolism. No. 271, East Taihang Road Changzhi, China.
Curr Diabetes Rev. 2019;15(4):277-283. doi: 10.2174/1573399814666180912130401.
Previous studies suggested that the single nucleotide polymorphisms of Pro12Ala located within the PPARG gene were significantly associated with the T2DM. Recently, the genetic studies on Pro12Ala were conducted in the different ethnic groups and the results of each study were shown to be inconsistent. Moreover, the systematic review has not been updated since 2000.
To further validate the risk of Pro12Ala for T2DM disease based on the genetic data.
The genetic studies on the Pro12Ala in the T2DM were searched in the PubMed and PMC database from January 2000 to October 2017. The meta-analysis was conducted with the CMA software.
The meta-analysis collected 14 studies including 20702 cases and 36227 controls. The combined analysis of all studies found that Pro12Ala was shown to be significantly associated with T2DM and the Ala allele played the increasing risks for the disease. Nevertheless, publication bias was detected in the combined analysis. The subgroup analysis indicated that Pro12Ala was found to be significant in the Caucasian and Chinese population. There was no heterogeneity and publication bias in these two groups.
The meta-analysis confirmed the evidence that the Pro12Ala was the susceptible variant for the decreasing risks for the T2DM.
先前的研究表明，位于PPARG基因内的Pro12Ala单核苷酸多态性与2型糖尿病显著相关。最近，针对Pro12Ala开展了不同种族群体的遗传学研究，每项研究的结果都显示不一致。此外，自2000年以来尚未更新系统评价。
基于遗传数据进一步验证Pro12Ala对2型糖尿病的风险。
检索2000年1月至2017年10月PubMed和PMC数据库中有关2型糖尿病中Pro12Ala的遗传学研究。使用CMA软件进行荟萃分析。
荟萃分析纳入14项研究，共20702例病例和36227例对照。所有研究的综合分析发现，Pro12Ala与2型糖尿病显著相关，Ala等位基因会增加患该疾病的风险。然而，在综合分析中检测到发表偏倚。亚组分析表明，Pro12Ala在白种人和中国人群中具有显著性。这两组均不存在异质性和发表偏倚。
荟萃分析证实了Pro12Ala是降低2型糖尿病风险的易感变异这一证据。
