Bäckman L, Ringdén O, Björkhem I, Lindbäck B
Transplantation. 1986 Oct;42(4):368-71. doi: 10.1097/00007890-198610000-00007.
In 83 renal transplant recipients, serum beta 2 microglobulin (beta 2m) levels were significantly elevated during pretransplant uremia, rejection, cyclosporine-induced nephrotoxicity, and infections. In patients with normal serum creatinine, 74% had elevated serum beta 2m levels. None of the cyclosporine-treated patients had normal levels of beta 2m. Patients with stable renal allograft function receiving cyclosporine showed significantly higher serum beta 2m (P less than 0.001) and serum creatinine (P less than 0.01) levels than azathioprine treated patients. Patients with an irreversible rejection showed significantly higher serum concentrations of beta 2m than patients experiencing a reversible rejection (P less than 0.001). During cytomegalovirus (CMV) infection the serum beta 2m levels were elevated compared with other infections (P less than 0.001), while the serum creatinine was not. However, infected patients had higher serum levels of beta 2m and creatinine than patients with stable renal allograft function (P less than 0.001). Serum beta 2m may therefore be useful in the early diagnosis of CMV infection. To conclude, serum beta 2m levels cannot distinguish between rejection, cyclosporine nephrotoxicity, or infection.
在83例肾移植受者中，血清β2微球蛋白（β2m）水平在移植前尿毒症、排斥反应、环孢素诱导的肾毒性及感染期间显著升高。血清肌酐正常的患者中，74%血清β2m水平升高。接受环孢素治疗的患者中，无一例β2m水平正常。接受环孢素治疗且肾移植功能稳定的患者血清β2m（P<0.001）和血清肌酐（P<0.01）水平显著高于接受硫唑嘌呤治疗的患者。发生不可逆排斥反应的患者血清β2m浓度显著高于发生可逆排斥反应的患者（P<0.001）。在巨细胞病毒（CMV）感染期间，血清β2m水平高于其他感染（P<0.001），而血清肌酐则不然。然而，感染患者的血清β2m和肌酐水平高于肾移植功能稳定的患者（P<0.001）。因此，血清β2m可能有助于CMV感染的早期诊断。总之，血清β2m水平无法区分排斥反应、环孢素肾毒性或感染。
