Mukuno K, Witmer R, Gruber P
Albrecht Von Graefes Arch Klin Exp Ophthalmol. 1977 Jun 28;202(4):245-57. doi: 10.1007/BF02387398.
Electron-microscopic analysis of iris biopsy material was carried out paying particular attention to vessels and infiltrating cells. Characteristic changes of vessels and cells were found in two cases. One showed abundant lymphodiapedesis, perivascular infiltration, and vessels appearing morphologically normal. The other showed diffuse infiltration of cells and numerous fenestrated newly formed vessels. In the latter, three different types of opening in the endothelium were observed: (1) separation of intercellular junctions; (2) small pores or defects in the endothelium, and (3) large holes or defects in the endothelium. Cell leakage from normal and newly formed vessels was considered. We concluded that lymphocytes may migrate through the cytoplasm within membrane-bounded vesicles in normal vessels, whereas in newly formed fenestrated vessels cells, including small lymphocytes, may pass through three different types of opening in the endothelium.
对虹膜活检材料进行了电子显微镜分析，特别关注血管和浸润细胞。在两例中发现了血管和细胞的特征性变化。一例显示大量淋巴细胞渗出、血管周围浸润，且血管形态正常。另一例显示细胞弥漫性浸润以及许多有窗孔的新形成血管。在后者中，观察到内皮细胞有三种不同类型的开口：（1）细胞间连接分离；（2）内皮细胞中的小孔或缺陷；（3）内皮细胞中的大洞或缺陷。研究了正常血管和新形成血管中的细胞渗漏情况。我们得出结论，淋巴细胞可能在正常血管中通过膜结合囊泡内的细胞质迁移，而在新形成的有窗孔血管中，包括小淋巴细胞在内的细胞可能通过内皮细胞的三种不同类型开口。
