Kontrec Darko, Jurin Mladenka, Jakas Andreja, Roje Marin
Laboratory for Chiral Technologies, Division of Organic Chemistry and Biochemistry, Ruder Bošković Institute, Bijenička Cesta 54, 10 000 Zagreb, Croatia.
Molecules. 2024 May 9;29(10):2213. doi: 10.3390/molecules29102213.
In this paper, the preparation of three new polysaccharide-type chiral stationary phases (CSPs) based on levan carbamates (3,5-dimethylphenyl, 4-methylphenyl, and 1-naphthyl) is described. The enantioseparation of (±)--β-lactam ureas - was investigated by high-performance liquid chromatography (HPLC) on six different chiral columns (Chiralpak AD-3, Chiralcel OD-3, Chirallica PST-7, Chirallica PST-8, Chirallica PST-9, and Chirallica PST-10) in the polar organic mode, using pure methanol (MeOH), ethanol (EtOH), and acetonitrile (ACN). Apart from the Chirallica PST-9 column (based on levan (1-naphthylcarbamate), the columns exhibited a satisfactory chiral recognition ability for the tested -β-lactam ureas -.
本文描述了基于果聚糖氨基甲酸酯（3,5-二甲基苯基、4-甲基苯基和1-萘基）制备三种新型多糖类手性固定相（CSPs）的方法。通过高效液相色谱（HPLC）在极性有机模式下，使用纯甲醇（MeOH）、乙醇（EtOH）和乙腈（ACN），在六种不同的手性柱（Chiralpak AD-3、Chiralcel OD-3、Chirallica PST-7、Chirallica PST-8、Chirallica PST-9和Chirallica PST-10）上研究了（±）-β-内酰胺脲的对映体分离。除了Chirallica PST-9柱（基于果聚糖（1-萘基氨基甲酸酯））外，这些柱对测试的β-内酰胺脲表现出令人满意的手性识别能力。
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