Key Laboratory of Functional Small Organic Molecule, Ministry of Education, and Jiangxi Province's Key Laboratory of Green Chemistry, Jiangxi Normal University, Nanchang, Jiangxi 330022, China.
Org Biomol Chem. 2018 Nov 21;16(45):8724-8731. doi: 10.1039/c8ob01429a.
A novel and efficient protocol for the direct C-4 alkylation of quinazoline-3-oxides via radical oxidative coupling between quinazoline 3-oxides and ethers in the presence of TBHP was developed. The reaction proceeded smoothly under metal-free conditions, which provided quinazoline-containing heterocyclic molecules in moderate to good yields.
开发了一种通过在 TBHP 存在下，喹唑啉 3-氧化物与醚之间的自由基氧化偶联，直接 C-4 烷基化喹唑啉-3-氧化物的新型高效方法。该反应在无金属条件下顺利进行，为中等至良好收率提供了含喹唑啉的杂环分子。
