Department of Neurology, Istanbul Haseki Training and Research Hospital, Istanbul, Turkey.
Nöroloji Anabilim Dalı, Istanbul Haseki Eğitim ve Araştırma Hastanesi, Adnan Adıvar Caddesi, Aksaray, 34130, Fatih, Istanbul, Türkiye.
Neurol Sci. 2018 Dec;39(12):2129-2134. doi: 10.1007/s10072-018-3558-0. Epub 2018 Sep 12.
Similar clinical characteristics of epilepsy and migraine and the prevalence of their comorbidity have been investigated for years. The present study investigated the relationship between epilepsy and headache.
A total of 420 epilepsy patients, who visited epilepsy outpatient clinic within 6-month period between January 2016 and June 2016, were questioned whether they have headache. Age, gender, duration of epilepsy, type of seizures, and temporal relationship of headache with seizure were investigated in the patients with headache.
Headache was detected in 111 (26%) of 420 epilepsy patients. The prevalence of migraine was 15%. When the temporal relationship of headache with seizure was evaluated, interictal headache was found to be the most common type with a percentage of 74.8%. No significant difference was determined between the patients with migraine and non-migraine headache in terms of age, gender, duration of epilepsy, age at the onset of epilepsy, type of seizure, and electroencephalography findings. The prevalence of interictal headache was statistically significantly higher in migraine patients as compared to that of non-migraine patients (p < 0.001); however, the prevalence of preictal headache and the prevalence of postictal headache were significantly lower (p = 0.001 and p < 0.001, respectively).
The prevalence of headache and the prevalence of migraine, which are considered to be pathogenetically linked to epilepsy, were not different in epilepsy patients as compared to that of the general population. Different outcomes and percentages in other studies suggest that pathogenesis of headache is multifactorial and that different diagnostic criteria might have been taken into consideration.
多年来，人们一直在研究癫痫和偏头痛的临床特征相似以及它们同时存在的发病率。本研究旨在探讨癫痫与头痛之间的关系。
本研究共纳入 420 名在 2016 年 1 月至 6 月期间的 6 个月内就诊于癫痫门诊的癫痫患者，询问他们是否有头痛。对头痛患者的年龄、性别、癫痫持续时间、癫痫发作类型以及头痛与癫痫发作的时间关系进行了调查。
在 420 名癫痫患者中，有 111 名（26%）患者出现头痛。偏头痛的患病率为 15%。当评估头痛与癫痫发作的时间关系时，发现间发性头痛是最常见的类型，占 74.8%。偏头痛和非偏头痛头痛患者在年龄、性别、癫痫持续时间、癫痫发作起始年龄、癫痫发作类型和脑电图表现方面无显著差异。与非偏头痛头痛患者相比，偏头痛患者的间发性头痛患病率显著更高（p<0.001）；然而，先兆性头痛和癫痫后头痛的患病率显著更低（p=0.001 和 p<0.001）。
与一般人群相比，癫痫患者头痛的患病率和偏头痛的患病率并无差异，这两种疾病被认为与癫痫的发病机制有关。不同研究的不同结果和百分比表明，头痛的发病机制是多因素的，并且可能考虑了不同的诊断标准。
