Carson L F, Twiggs L B, Fukushima M, Ostrow R S, Faras A J, Okagaki T
Am J Obstet Gynecol. 1986 Oct;155(4):784-9. doi: 10.1016/s0002-9378(86)80021-7.
Immunologic evaluations of women with genital neoplasia-papilloma syndrome demonstrated the presence of subclinical immunodeficiency when compared with results in 20 control women. All patients with genital neoplasia-papilloma syndrome were previously found to have human papillomavirus deoxyribonucleic acid in genital neoplasias or papillomas occurring either synchronously (in at least two genital organs at the same time) or metachronously (at different times during a period of months to years). Immunologic tests included blastogenic responses of lymphocytes to mitogens (phytohemagglutinin, concanavalin A, pokeweed mitogen, and tetanus antigen) and lymphocyte phenotyping with the use of monoclonal antibodies (OKT3, OKT4, OKT8, and OKT11). As compared with those of control subjects, the responses of the lymphocytes of patients with genital neoplasia-papilloma syndrome to mitogens were significantly decreased. The group with genital neoplasia-papilloma syndrome had a significantly higher percentage of suppressor-cytotoxic T cells (OKT8-positive cells) when compared with that of control subjects (mean 33% versus 18%) and a lower proportion of helper T cells (OKT4-positive cells) when compared with that of control subjects (35% versus 50%). The mean helper-to-suppressor/cytotoxic T-cell ratio (mean OKT4/OKT8 ratio) in the human papillomavirus-infected women was 1.72 +/- 0.29 (SE) as compared with 3.21 +/- 0.33 (SE) in the control group, demonstrating a significant reduction of the ratio in the patients with genital neoplasia-papilloma syndrome. These findings suggest that patients with genital neoplasia-papilloma syndrome have a reduced suppressor/cytotoxic T-cell ratio (mean OKT4/OKT8 ratio; that in the human papillomavirus-infected women was 1.72 +/- 0.29 (SE) as compared with 3.21 +/- 0.33 (SE) in the control group, demonstrating a significant reduction of the ratio in patients with genital neoplasia-papilloma syndrome. These findings suggest that patients with genital neoplasia-papilloma syndrome have reduced immunocompetence of unknown etiology.
与20名对照女性的结果相比，对患有生殖器肿瘤 - 乳头瘤综合征的女性进行的免疫学评估显示存在亚临床免疫缺陷。先前发现，所有患有生殖器肿瘤 - 乳头瘤综合征的患者在同时发生（至少在两个生殖器官同时发生）或异时发生（在数月至数年的不同时间）的生殖器肿瘤或乳头瘤中都有人乳头瘤病毒脱氧核糖核酸。免疫学检测包括淋巴细胞对有丝分裂原（植物血凝素、刀豆球蛋白A、商陆有丝分裂原和破伤风抗原）的增殖反应，以及使用单克隆抗体（OKT3、OKT4、OKT8和OKT11）进行淋巴细胞表型分析。与对照受试者相比，患有生殖器肿瘤 - 乳头瘤综合征的患者淋巴细胞对有丝分裂原的反应显著降低。与对照受试者相比，生殖器肿瘤 - 乳头瘤综合征组的抑制性细胞毒性T细胞（OKT8阳性细胞）百分比显著更高（平均33%对18%），辅助性T细胞（OKT4阳性细胞）比例更低（35%对50%）。人乳头瘤病毒感染女性的平均辅助性T细胞与抑制性/细胞毒性T细胞比例（平均OKT4/OKT8比例）为1.72±0.29（标准误），而对照组为3.21±0.33（标准误），表明生殖器肿瘤 - 乳头瘤综合征患者的该比例显著降低。这些发现表明，患有生殖器肿瘤 - 乳头瘤综合征的患者免疫能力降低，病因不明。
