复发性呼吸道乳头状瘤病中HLA-DQ3表型富集及I类主要组织相容性复合体抗原表达降低
Enriched HLA-DQ3 phenotype and decreased class I major histocompatibility complex antigen expression in recurrent respiratory papillomatosis.
作者信息
Bonagura V R, Siegal F P, Abramson A L, Santiago-Schwarz F, O'Reilly M E, Shah K, Drake D, Steinberg B M
机构信息
Department of Pediatrics, Schneider Children's Hospital, New Hyde Park, New York 11042, USA.
出版信息
Clin Diagn Lab Immunol. 1994 May;1(3):357-60. doi: 10.1128/cdli.1.3.357-360.1994.
Abstract
Respiratory papillomas, caused by human papillomaviruses, are benign tumors that recur following removal. We evaluated immune function and major histocompatibility complex (MHC) phenotype and expression in these patients. MHC-independent immune function appeared normal. The frequency of peripheral blood MHC class II phenotypes was highly enriched for DQ3 and DR11, one split of DR5. Class I MHC antigen expression on papilloma tissue was markedly reduced. Together, these phenomena may facilitate papillomavirus evasion of the cellular immune response.
摘要
由人乳头瘤病毒引起的呼吸道乳头瘤是切除后会复发的良性肿瘤。我们评估了这些患者的免疫功能以及主要组织相容性复合体（MHC）的表型和表达情况。不依赖MHC的免疫功能看起来正常。外周血MHC II类表型的频率在DQ3和DR11（DR5的一个分支）中高度富集。乳头瘤组织上I类MHC抗原的表达明显降低。这些现象共同作用可能会促使乳头瘤病毒逃避免疫细胞反应。
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