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类脂蛋白沉积症:联合分次二氧化碳激光和非剥脱性射频进行皮肤表面重建:1例罕见病例报告

Lipoid Proteinosis: Skin Resurfacing with Combination of Fractional CO and Non-ablative Radio Frequency: A Rare Case Report.

作者信息

Madura Chandraiah, Priya Arti, Chandrashekar Byalekere Shivanna

机构信息

Department of Dermatology, CUTIS Academy of Cutaneous Sciences, Bengaluru, Karnataka, India.

出版信息

J Cutan Aesthet Surg. 2018 Apr-Jun;11(2):91-94. doi: 10.4103/JCAS.JCAS_29_18.

DOI:10.4103/JCAS.JCAS_29_18
PMID:30210213
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6128159/
Abstract

Lipoid proteinosis (LP) is a rare autosomal-recessive genodermatosis, characterized by the deposition of amorphous hyaline-like material in different parts of the body, especially the skin and mucous membranes. Disfiguring lesions predominantly affect the facial appearance. No curative therapy and treatment options limited to symptomatic approaches are available. Facial disfigurement in this disease may have a huge negative effect on the patients' psychology and quality of life. With this regard, the patients may benefit very much from the treatments that enhance their cosmetic outlook. We present a 19-year-old female patient with LP who came to us seeking treatment for her facial lesions. She was treated with a combination regimen of fractional carbon dioxide and non-ablative radio frequency with good clinical and aesthetic outcome.

摘要

类脂蛋白沉积症(LP)是一种罕见的常染色体隐性遗传性皮肤病,其特征是无定形透明样物质沉积于身体不同部位,尤其是皮肤和黏膜。毁容性损害主要影响面部外观。目前尚无治愈性疗法,治疗选择仅限于对症治疗。该疾病导致的面部毁容可能对患者心理和生活质量产生巨大负面影响。鉴于此,改善容貌的治疗可能会使患者受益匪浅。我们报告一名19岁患类脂蛋白沉积症的女性患者,她前来寻求面部皮损的治疗。她接受了分次二氧化碳激光和非剥脱性射频联合治疗方案,取得了良好的临床和美学效果。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a3/6128159/f4626c82d293/JCAS-11-91-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a3/6128159/73e51ea8ef99/JCAS-11-91-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a3/6128159/f4626c82d293/JCAS-11-91-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a3/6128159/73e51ea8ef99/JCAS-11-91-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/c5a3/6128159/f4626c82d293/JCAS-11-91-g002.jpg

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Indian J Dermatol. 2020 Jan-Feb;65(1):53-56. doi: 10.4103/ijd.IJD_523_18.
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本文引用的文献

1
Treatment of lipoid proteinosis with ablative Er:YAG laser resurfacing.
Dermatol Ther. 2015 Sep-Oct;28(5):291-5. doi: 10.1111/dth.12247. Epub 2015 Jun 2.
2
Lipoid proteinosis (Urbach-Wiethe disease) in two siblings.两名兄弟姐妹患类脂蛋白沉积症(乌尔巴赫-维特病)。
Indian Dermatol Online J. 2014 Dec;5(Suppl 2):S95-7. doi: 10.4103/2229-5178.146168.
3
Lipoid proteinosis in a six-year-old child.一名六岁儿童的类脂蛋白沉积症。
Indian Dermatol Online J. 2012 Jan;3(1):25-7. doi: 10.4103/2229-5178.93490.
细胞外基质蛋白1基因第9外显子中的一种新型无义突变与类脂蛋白沉积症相关:一例报告。
SAGE Open Med Case Rep. 2019 May 19;7:2050313X19850359. doi: 10.1177/2050313X19850359. eCollection 2019.
4
Multisource, Phase-controlled Radiofrequency for Treatment of Skin Laxity: Correlation Between Clinical and In-vivo Confocal Microscopy Results and Real-Time Thermal Changes.多源相控射频治疗皮肤松弛:临床与活体共聚焦显微镜检查结果及实时热变化之间的相关性
J Clin Aesthet Dermatol. 2011 Jan;4(1):28-35.
5
Clinical and histopathological response to acitretin therapy in lipoid proteinosis.类脂蛋白沉积症患者接受阿维 A 酯治疗的临床和组织病理学反应。
J Dermatolog Treat. 2011 Jun;22(3):178-83. doi: 10.3109/09546631003639407. Epub 2010 Jul 28.
6
Hyalinosis cutis et mucosae: a 30 year follow up of a female patient.皮肤黏膜透明变性:一名女性患者的30年随访
Eur J Dermatol. 2004 Sep-Oct;14(5):310-3.
7
Histological and ultrastructural evaluation of the effects of a radiofrequency-based nonablative dermal remodeling device: a pilot study.基于射频的非剥脱性皮肤重塑设备效果的组织学和超微结构评估:一项初步研究。
Arch Dermatol. 2004 Feb;140(2):204-9. doi: 10.1001/archderm.140.2.204.
8
Extracellular matrix protein 1 gene (ECM1) mutations in lipoid proteinosis and genotype-phenotype correlation.类脂蛋白沉积症中的细胞外基质蛋白1基因(ECM1)突变及基因型-表型相关性
J Invest Dermatol. 2003 Mar;120(3):345-50. doi: 10.1046/j.1523-1747.2003.12073.x.
9
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Clin Exp Dermatol. 2002 Nov;27(8):624-9. doi: 10.1046/j.1365-2230.2002.01143.x.
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