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异基因造血干细胞移植后外周血淋巴细胞对巨细胞病毒血清阳性的反应

Peripheral blood lymphocyte responses to cytomegalovirus seropositivity after allogeneic-hematopoietic stem cell transplantation.

作者信息

Zhang Jiexin, Chen Xian, Rong Guodong, Xu Ting, Zhao Hong, Chen Dan, Wu Lei, Huang Peijun, Wang Fang

机构信息

Department of Laboratory Medicine, The First Affiliated Hospital of Nanjing Medical University, 210029, Nanjing, China,

National Key Clinical Department of Laboratory Medicine, 210029, Nanjing, China,

出版信息

Onco Targets Ther. 2018 Aug 24;11:5143-5150. doi: 10.2147/OTT.S160178. eCollection 2018.

DOI:10.2147/OTT.S160178
PMID:30210235
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6114473/
Abstract

BACKGROUND

The main purpose of this study was to investigate the relationship among cytomegalovirus (CMV) viremia, peripheral immune cells alternations, and leukemia prognosis.

PATIENTS AND METHODS

We studied 90 leukemia patients who underwent allogeneic hematopoietic stem cell transplantation (allo-HSCT) from 2008 to 2015. Their complete clinical laboratory data were collected until 1 year after transplantation.

RESULTS

All patients were serum CMV negative before allo-HSCT. After transplantation, the CMV reactivation group showed increased peripheral CD8 T cells and decreased CD4 T cells and B cells. However, CD8/CD4 ratio and B cells restored by control of CMV infection due to 2 months maximum course of ganciclovir treatment. CMV seropositivity was positively related to leukemia-free survival (LFS) of all recruited leukemia types.

CONCLUSION

In summary, CMV drives immune cell post-transplantation fluctuation, which also favors LFS of leukemia partly resulted from CD8 T cells.

摘要

背景

本研究的主要目的是探讨巨细胞病毒（CMV）病毒血症、外周免疫细胞变化与白血病预后之间的关系。

患者与方法

我们研究了2008年至2015年间接受异基因造血干细胞移植（allo-HSCT）的90例白血病患者。收集他们直至移植后1年的完整临床实验室数据。

结果

所有患者在allo-HSCT前血清CMV均为阴性。移植后，CMV再激活组外周血CD8 T细胞增加，CD4 T细胞和B细胞减少。然而，由于更昔洛韦治疗最长疗程为2个月，CMV感染得到控制后，CD8/CD4比值和B细胞得以恢复。CMV血清阳性与所有纳入的白血病类型的无白血病生存期（LFS）呈正相关。

结论

总之，CMV驱动移植后免疫细胞波动，这也部分地有利于白血病的LFS，其部分原因是CD8 T细胞。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/d5eb3db7ece5/ott-11-5143Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/53c0682b2071/ott-11-5143Fig1.jpg
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https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/bcb1414a0554/ott-11-5143Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/02727ec1c4e9/ott-11-5143Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/d5eb3db7ece5/ott-11-5143Fig5.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/53c0682b2071/ott-11-5143Fig1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/fdb860626040/ott-11-5143Fig2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/bcb1414a0554/ott-11-5143Fig3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/02727ec1c4e9/ott-11-5143Fig4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/a4fc/6114473/d5eb3db7ece5/ott-11-5143Fig5.jpg

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