Giraud P, Affolter H U, Hotchkiss A, Castanas E, Oliver C, Eiden L E
Ann Endocrinol (Paris). 1986;47(1):40-2.
Enkephalin peptides (ENK) are co-released with catecholamines from bovine chromaffin cells in culture. Drugs mimicking the effects of c-AMP increase ENK biosynthesis by increasing ENK mRNA, but are uneffective on ENK secretion. Nicotine, which causes a rapid release of ENK from these cells, also induces an increase in ENK biosynthesis and ENK mRNA. Reserpine enhance ENK precursor processing. The actions of these different pharmacological agents show that ENK biosynthesis is regulated at different levels in chromaffin cells.
脑啡肽（ENK）在培养的牛嗜铬细胞中与儿茶酚胺共同释放。模拟c-AMP作用的药物通过增加ENK mRNA来增加ENK生物合成，但对ENK分泌无效。尼古丁可使这些细胞快速释放ENK，同时也会诱导ENK生物合成及ENK mRNA增加。利血平可增强ENK前体的加工过程。这些不同药理剂的作用表明，嗜铬细胞中ENK生物合成在不同水平受到调控。
