miR-302b与EphA2的关系及其在胃癌中的临床意义。
The relationship between miR-302b and EphA2 and their clinical significance in gastric cancer.
作者信息
Tang Lanhua, Hu Huabin, He Yijing, Mcleod Howard L, Xiao Desheng, Chen Pan, Shen Liangfang, Zeng Shan, Yin Xianli, Ge Jie, Li Li, Ma Jian, Chen Zihua, Huang Jin
机构信息
Department of Oncology, Xiangya Hospital, Central South University, Changsha, 410008, China.
The Sixth Affiliated Hospital of Sun Yat-Sen University, Guangzhou, 510655, China.
出版信息
J Cancer. 2018 Aug 6;9(17):3109-3116. doi: 10.7150/jca.25235. eCollection 2018.
EphA2 is a crucial oncogene in gastric cancer (GC) development and metastasis, and miR-302b can target EphA2 in gastric cancer. This study plans to investigate their relationship and clinical significance in clinical samples. We explored the correlation of the expression of EphA2 and miR-302b, and their clinical significance in the training (n=226) cohort of GC patients, and then validated the results in the validation (n=128) cohort. miR-302b was remarkably downregulated in GC tissues, while high EphA2 expression were detected, and they were inversely correlated both in mRNA and protein, (r=-0.4209, <0.0001; r=-0.336, P <0.001, respectively). Furthermore, the pattern of high EphA2 and low miR-302b expression were found to be associated with poor overall survival in stage IV GC patients in both training and validation cohort. The expression of miR-302b and EphA2 was inversely correlated, and had prognostic significance on GC in clinic.
EphA2是胃癌（GC）发生和转移中的关键癌基因，且miR-302b可在胃癌中靶向EphA2。本研究计划在临床样本中探究它们之间的关系及临床意义。我们在GC患者的训练队列（n = 226）中探讨了EphA2和miR-302b表达的相关性及其临床意义，随后在验证队列（n = 128）中验证结果。miR-302b在GC组织中显著下调，同时检测到EphA2高表达，它们在mRNA和蛋白质水平均呈负相关（分别为r = -0.4209，P <0.0001；r = -0.336，P <0.001）。此外，在训练队列和验证队列中均发现，EphA2高表达和miR-302b低表达模式与IV期GC患者的总生存期较差相关。miR-302b和EphA2的表达呈负相关，且在临床上对GC具有预后意义。
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