Li Yanling, Gan Sijie, Ren Lin, Yuan Long, Liu Junlan, Wang Wei, Wang Xiaoyu, Zhang Yi, Jiang Jun, Zhang Fan, Qi Xiaowei
Breast Disease Center, Southwest Hospital, Third Military Medical University Chongqing 400038, China.
Am J Cancer Res. 2018 Aug 1;8(8):1343-1355. eCollection 2018.
Replication factor C (RFC) family is a complex comprised of the RFC1, RFC2, RFC3, RFC4, and RFC5 subunits, which acts as a primer recognition factor for DNA polymerase. It is reported that RFC, biologically active in various malignant tumors, may play an important role in the proliferation, progression, invasion, and metastasis of cancer cells. It could act as an oncogene or tumor suppressor gene based on the cellular and histological characteristics of the tumor. In this review, we summarized the updated researches on the structure, physiological function, and expression pattern of RFC in a variety of tumors, the underlying mechanisms on carcinogenesis, and the potentials of RFC family members in the diagnosis and prognosis prediction.
复制因子C（RFC）家族是一个由RFC1、RFC2、RFC3、RFC4和RFC5亚基组成的复合体，其作为DNA聚合酶的引物识别因子发挥作用。据报道，RFC在多种恶性肿瘤中具有生物学活性，可能在癌细胞的增殖、进展、侵袭和转移中发挥重要作用。根据肿瘤的细胞和组织学特征，它可以作为癌基因或肿瘤抑制基因。在本综述中，我们总结了关于RFC在各种肿瘤中的结构、生理功能、表达模式、致癌的潜在机制以及RFC家族成员在诊断和预后预测方面的最新研究。
