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骨质疏松性椎体骨折的非手术及手术治疗:德国骨科与创伤学会(DGOU)脊柱分会的建议

Nonsurgical and Surgical Management of Osteoporotic Vertebral Body Fractures: Recommendations of the Spine Section of the German Society for Orthopaedics and Trauma (DGOU).

作者信息

Blattert Thomas R, Schnake Klaus J, Gonschorek Oliver, Gercek Erol, Hartmann Frank, Katscher Sebastian, Mörk Sven, Morrison Robert, Müller Michael, Partenheimer Axel, Piltz Stefan, Scherer Michael A, Ullrich Bernhard W, Verheyden Akhil, Zimmermann Volker

机构信息

Schwarzach Orthopaedic Clinic, Schwarzach, Germany.

Schön Klinik Nürnberg Fürth, Fürth, Germany.

出版信息

Global Spine J. 2018 Sep;8(2 Suppl):50S-55S. doi: 10.1177/2192568217745823. Epub 2018 Sep 7.

Abstract

STUDY DESIGN

Prospective clinical cohort study (data collection); expert opinion (recommendation development).

OBJECTIVES

Treatment options for nonsurgical and surgical management of osteoporotic vertebral body fractures are widely differing. Based on current literature, the knowledge of the experts, and their classification for osteoporotic fractures (OF classification) the Spine Section of the German Society for Orthopaedics and Trauma has now introduced general treatment recommendations.

METHODS

a total of 707 clinical cases from 16 hospitals were evaluated. An OF classification-based score was developed to guide in the option of nonsurgical versus surgical management. For every classification type, differentiated treatment recommendations were deduced. Diagnostic prerequisites for reproducible treatment recommendations were defined: conventional X-rays with consecutive follow-up images (standing position whenever possible), magnetic resonance imaging, and computed tomography scan. OF classification allows for upgrading of fracture severity during the course of radiographic follow-up. The actual classification type is decisive for the score.

RESULTS

A score of less than 6 points advocates nonsurgical management; more than 6 points recommend surgical management. The primary goal of treatment is fast and painless mobilization. Because of expected comorbidities in this age group, minimally invasive procedures are being preferred. As a general rule, stability is more important than motion preservation. It is mandatory to restore the physiological loading capacity of the spine. If the patient was in a compensated unbalanced state at the time of fracture, reconstruction of the individual prefracture sagittal profile is sufficient. Instrumentation technique has to account for compromised bone quality. We recommend the use of cement augmentation or high purchase screws. The particular situations of injuries with neurological impairment; necessity to fuse; multiple level fractures; consecutive and adjacent fractures; fractures in ankylosing spondylitis are being addressed separately.

CONCLUSIONS

The therapeutic recommendations presented here provide a reliable and reproducible basis to decide for treatment choices available. However, intermediate clinical situations remain with a score of 6 points allowing for both nonsurgical and surgical options. As a result, individualized treatment decisions may still be necessary. In the next step, the recommendations presented will be further evaluated in a multicenter controlled clinical trial.

摘要

研究设计

前瞻性临床队列研究(数据收集);专家意见(推荐制定)。

目的

骨质疏松性椎体骨折的非手术和手术治疗方案差异很大。基于当前文献、专家知识以及他们对骨质疏松性骨折的分类(OF分类),德国骨科与创伤学会脊柱分会现已推出一般治疗建议。

方法

对16家医院的707例临床病例进行评估。制定了基于OF分类的评分,以指导非手术与手术治疗的选择。针对每种分类类型,推导了差异化的治疗建议。定义了可重复治疗建议的诊断前提条件:常规X线检查及连续的随访影像(尽可能采用站立位)、磁共振成像和计算机断层扫描。OF分类允许在影像学随访过程中提升骨折严重程度。实际分类类型对评分起决定性作用。

结果

评分低于6分主张非手术治疗;高于6分推荐手术治疗。治疗的主要目标是快速且无痛地恢复活动能力。鉴于该年龄组预期的合并症,首选微创手术。一般而言,稳定性比保留活动度更重要。必须恢复脊柱的生理负荷能力。如果患者在骨折时处于代偿性失衡状态,重建骨折前的个体矢状面形态即可。器械技术必须考虑到骨质受损情况。我们建议使用骨水泥强化或高把持力螺钉。分别讨论了伴有神经损伤的损伤特殊情况;融合的必要性;多节段骨折;连续和相邻骨折;强直性脊柱炎中的骨折。

结论

此处提出的治疗建议为决定可用的治疗选择提供了可靠且可重复的依据。然而,评分6分的中间临床情况仍允许非手术和手术两种选择。因此,可能仍需要个体化的治疗决策。下一步,将在多中心对照临床试验中进一步评估所提出的建议。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b36a/6130106/798f22fc1657/10.1177_2192568217745823-fig1.jpg

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