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局部应用洋甘菊油对剖宫产术后肠道功能的影响:一项随机对照试验

Effect of Topical Chamomile Oil on Postoperative Bowel Activity after Cesarean Section: A Randomized Controlled Trial.

作者信息

Khadem Ebrahim, Shirazi Mahboobeh, Janani Leila, Rahimi Roja, Amiri Parastoo, Ghorat Fereshteh

机构信息

Department of Persian Medicine, Tehran University of Medical Sciences, Tehran, Iran.

Maternal, Fetal and Neonatal Research Center, Tehran University of Medical Sciences, Tehran, Iran.

出版信息

J Res Pharm Pract. 2018 Jul-Sep;7(3):128-135. doi: 10.4103/jrpp.JRPP_17_103.

Abstract

OBJECTIVE

Postoperative ileus (POI) is a common complication after surgery that requires a multifactorial therapeutic approach. This study aims to assess the effect of topical chamomile oil on postoperative bowel activity after cesarian section.

METHODS

This randomized controlled trial was carried out in 2015 at Chamran Hospital in Iran. A block randomization list was generated for 142 parturient divided into three groups. In the intervention group (arm A) ( = 47), chamomile oil was applied topically on abdominal region after the stability of the patient. Placebo group (arm B) ( = 47) received placebo oil and control group (arm C) ( = 48) had no intervention. A recovery program was used after surgery for all participants. The primary outcome was time to first flatus. Secondary outcomes were time to bowel sounds, defecation, return of appetite, hospital stay, and rate of nausea and vomiting, abdominal pain.

FINDINGS

Times to first flatus were significantly shorter in Group A (arm A vs. B, < 0.001 and arm A vs. C, < 0.001). In addition, time to first bowel sounds (arm A vs. B, < 0.001 and arm A vs. C, < 0.001) and return of appetite (arm A vs. B, < 0.001 and arm A vs. C, < 0.001) were significantly shorter in arm A. The times from surgery to first defecation were shorter in Group A versus B and C. However, there were no statistically significant differences between three groups.

CONCLUSION

These results suggest that topical chamomile oil has a potential therapeutic effect on gastrointestinal motility and can reduce the duration of POI.

摘要

目的

术后肠梗阻(POI)是手术后常见的并发症,需要采取多因素治疗方法。本研究旨在评估局部应用洋甘菊油对剖宫产术后肠道活动的影响。

方法

这项随机对照试验于2015年在伊朗的查姆兰医院进行。为142名产妇生成了一个区组随机化列表,将其分为三组。干预组(A组)(n = 47),在患者病情稳定后,将洋甘菊油局部涂抹于腹部区域。安慰剂组(B组)(n = 47)接受安慰剂油,对照组(C组)(n = 48)不进行干预。所有参与者术后均采用康复方案。主要结局是首次排气时间。次要结局包括肠鸣音恢复时间、排便时间、食欲恢复时间、住院时间以及恶心呕吐发生率、腹痛情况。

结果

A组首次排气时间明显更短(A组与B组比较,P < 0.001;A组与C组比较,P < 0.001)。此外,A组首次肠鸣音恢复时间(A组与B组比较,P < 0.001;A组与C组比较,P < 0.001)和食欲恢复时间(A组与B组比较,P < 0.001;A组与C组比较,P < 0.001)也明显更短。A组从手术到首次排便的时间比B组和C组短。然而,三组之间在这方面没有统计学上的显著差异。

结论

这些结果表明,局部应用洋甘菊油对胃肠动力具有潜在治疗作用,可缩短POI的持续时间。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/40e3/6121760/8ed998b7be7e/JRPP-7-128-g001.jpg

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