病毒转化的T细胞和B细胞中的白细胞介素1α信使核糖核酸
Interleukin 1 alpha mRNA in virus-transformed T and B cells.
作者信息
Noma T, Nakamura T, Maeda M, Okada M, Taniguchi Y, Tagaya Y, Yaoita Y, Yodoi J, Honjo T
出版信息
Biochem Biophys Res Commun. 1986 Aug 29;139(1):353-60. doi: 10.1016/s0006-291x(86)80121-8.
IL-1 alpha cDNA clone was isolated from a T cell line infected by the human T lymphotropic retrovirus type-I (HTLV-I/ATLV). We found significant amounts of mRNA hybridizing to IL-1 alpha cDNA not only in HTLV-I-transformed T cells but also in Epstein-Barr Virus-transformed B cells. A part of IL-2 receptor inducing activity in Adult T cell leukemia (ATL) cell line seems to be due to IL-1 alpha.
白细胞介素-1α（IL-1α）cDNA克隆是从一株被人类I型嗜T淋巴细胞逆转录病毒（HTLV-I/ATLV）感染的T细胞系中分离得到的。我们发现，不仅在HTLV-I转化的T细胞中，而且在爱泼斯坦-巴尔病毒转化的B细胞中，都有大量与IL-1α cDNA杂交的mRNA。成人T细胞白血病（ATL）细胞系中白细胞介素-2受体诱导活性的一部分似乎归因于IL-1α。
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