克隆相关的人T细胞白血病细胞系白细胞介素不同组合的表达
Expression of different combinations of interleukins by human T cell leukemic cell lines that are clonally related.
作者信息
Noma T, Nakakubo H, Sugita M, Kumagai S, Maeda M, Shimizu A, Honjo T
机构信息
Department of Medical Chemistry, Faculty of Medicine, Kyoto University, Japan.
出版信息
J Exp Med. 1989 May 1;169(5):1853-8. doi: 10.1084/jem.169.5.1853.
Abstract
We have analyzed expression patterns of 7 lymphokine mRNAs by Northern blot analyses in 19 different human T cell clones derived from patients with adult T cell leukemia. However, we were not able to reveal particular combinations of lymphokine production that allowed classification of human T cells. Especially, four clonally related leukemic lines that were established independently from the same patient with adult T cell leukemia expressed different combinations of lymphokine mRNAs, indicating that the expression of various lymphokines is not fixed but rather variable even among progenies of a single T cell clone.
摘要
我们通过Northern印迹分析，对来自成人T细胞白血病患者的19种不同人类T细胞克隆中的7种淋巴因子mRNA的表达模式进行了分析。然而，我们未能揭示出能够对人类T细胞进行分类的淋巴因子产生的特定组合。特别是，从同一名成人T细胞白血病患者独立建立的四个克隆相关白血病细胞系表达了不同的淋巴因子mRNA组合，这表明即使在单个T细胞克隆的后代中，各种淋巴因子的表达也不是固定不变的，而是可变的。
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