Quantz Katelin, Stiles Jean
Department of Veterinary Clinical Sciences, College of Veterinary Medicine, Purdue University, West Lafayette, Indiana.
Vet Ophthalmol. 2019 Mar;22(2):196-200. doi: 10.1111/vop.12610. Epub 2018 Sep 13.
Six dogs were diagnosed with punctal stenosis following the long-term use of topical neomycin-polymyxin B-dexamethasone (NPD). All patients were initially presented for ophthalmic diseases requiring ongoing anti-inflammatory therapy. Five of the 6 dogs had previously or concurrently been treated with topical anti-inflammatory medications other than NPD. One patient exclusively received topical NPD prior to the diagnosis of punctal stenosis. The onset of punctal stenosis following therapy with NPD was variable among patients, ranging from 4 months to over 1 year. Diagnosis of punctal stenosis was made based upon the presence of epiphora and visualization of fibrotic tissue over the nasolacrimal puncta.
六只犬长期使用新霉素-多粘菌素B-地塞米松（NPD）后被诊断为泪点狭窄。所有病犬最初均因需要持续抗炎治疗的眼科疾病就诊。6只犬中有5只曾接受过NPD以外的局部抗炎药物治疗，或同时接受过此类治疗。1只病犬在泪点狭窄诊断之前仅接受过局部NPD治疗。NPD治疗后泪点狭窄的发病时间在病犬中各不相同，从4个月到1年以上不等。泪点狭窄的诊断依据溢泪症状以及鼻泪管泪点处纤维化组织的可视情况。
