Grandhi Gowri Sankar, Selvakumar Jayaraman, Dana Suman, Baidya Mahiuddin
Department of Chemistry , Indian Institute of Technology Madras , Chennai 600 036 , India.
J Org Chem. 2018 Oct 5;83(19):12327-12333. doi: 10.1021/acs.joc.8b02116. Epub 2018 Sep 24.
Formal syntheses of natural products amorfrutin A, cajaninstilbene acid, hydrangenol, and macrophyllol have been accomplished on the basis of successive C-H bond functionalization of ready-stock benzoic acids. This concise strategy involves transition-metal-catalyzed directed C-H olefination, C-H hydroxylation, and acid-mediated C-H prenylation as key steps.
