Anhui Province Key Laboratory of Advanced Catalytic Materials and Reaction Engineering, School of Chemistry and Chemical Engineering , Hefei University of Technology , Hefei , 230009 , China.
Org Lett. 2018 Sep 21;20(18):5960-5963. doi: 10.1021/acs.orglett.8b02671. Epub 2018 Sep 13.
A new class of rhodium-catalyzed, C-H activation triggered [3 + 2] annulations of aromatic aldimines or ketimines and maleimides was reported in this study. A broad scope of general imines without electron-withdrawing groups were successfully activated and could effectively react with N-substituted maleimide to afford pericyclic, multichiral centered amines in good yields and with excellent diastereoselectivity.
本研究报道了一类新型铑催化的、C-H 活化引发的芳基醛亚胺或酮亚胺与马来酰亚胺的[3 + 2]环加成反应。该反应具有广泛的适用性，能够有效地与 N-取代的马来酰亚胺反应，以高收率和优异的非对映选择性得到多手性中心的稠环胺。
