Departments of Neurology.
Biostatistics.
Alzheimer Dis Assoc Disord. 2018 Oct-Dec;32(4):284-290. doi: 10.1097/WAD.0000000000000273.
Roughly 4% to 23% of the population embody stress prone personality and other traits characterizing a subclinical "broad autism phenotype" (BAP). Subjective cognitive impairment (SCI) among healthy elderly is associated with psychological distress leading us to predict BAP would be associated with SCI.
The Autism Spectrum Quotient, a self-administered 50 item questionnaire, was completed by 419 consecutive members of the Arizona APOE Cohort who underwent neuropsychological testing every 2 years. SCI was assessed with self and informant versions of the Multidimensional Assessment of Neurodegenerative Symptoms (MANS) Questionnaire.
A total of 45 individuals scored in the BAP range, designated BAP+, and the rest were BAP-. At entry, both Multidimensional Assessment of Neurodegenerative Symptoms Questionnaire Self and Informant scores were higher in the BAP+ group (P<0.0001). After age 60, the BAP+ group had greater annual increases in Multidimensional Assessment of Neurodegenerative Symptoms Questionnaire Self scores (0.05 vs. 0.02; difference=0.03; 95% confidence interval, 0.004-0.05; P=0.02) yet there was no difference between groups in memory decline. Over ~10 years 33 individuals developed mild cognitive impairment: 4 in the BAP+ group (8.9%) and 29 in the BAP- group (7.8%), P=0.77.
Individuals who meet criteria for the BAP have escalating SCI with age, but no greater rate of memory decline or clinical progression to mild cognitive impairment.
大约有 4%到 23%的人口具有易受压力影响的个性和其他特征，这些特征构成了亚临床的“广泛自闭症表型”（BAP）。健康老年人的主观认知障碍（SCI）与心理困扰有关，这使我们预测 BAP 与 SCI 有关。
自闭症谱系商数（Autism Spectrum Quotient）是一种自我管理的 50 项问卷，由 419 名连续参加亚利桑那州 APOE 队列的成员完成，他们每两年接受一次神经心理测试。SCI 通过多维神经退行性症状评估量表（Multidimensional Assessment of Neurodegenerative Symptoms Questionnaire）的自我和知情者版本进行评估。
共有 45 人在 BAP 范围内得分，被指定为 BAP+，其余人则为 BAP-。在进入研究时，BAP+组的多维神经退行性症状评估量表自我和知情者得分均较高（P<0.0001）。60 岁以后，BAP+组的多维神经退行性症状评估量表自我评分每年增加幅度更大（0.05 比 0.02；差异=0.03；95%置信区间，0.004-0.05；P=0.02），但两组在记忆下降方面没有差异。在大约 10 年的时间里，有 33 人发展为轻度认知障碍：BAP+组有 4 人（8.9%），BAP-组有 29 人（7.8%），P=0.77。
符合 BAP 标准的个体随着年龄的增长 SCI 逐渐加重，但记忆下降率或向轻度认知障碍的临床进展率没有更高。
