Anitha D, Subburaj Karupppasamy, Kopp Felix K, Mei Kai, Foehr Peter, Burgkart Rainer, Sollmann Nico, Maegerlein Christian, Kirschke Jan S, Noel Peter B, Baum Thomas
Department of Radiology.
Department of Orthopaedic Surgery, Biomechanical Laboratory, and.
J Comput Assist Tomogr. 2019 Jan/Feb;43(1):61-65. doi: 10.1097/RCT.0000000000000788.
Statistical iterative reconstruction (SIR) using multidetector computed tomography (MDCT) is a promising alternative to standard filtered back projection (FBP), because of lower noise generation while maintaining image quality. Hence, we investigated the feasibility of SIR in predicting MDCT-based bone mineral density (BMD) and vertebral bone strength from finite element (FE) analysis. The BMD and FE-predicted bone strength derived from MDCT images reconstructed using standard FBP (FFBP) and SIR with (FSIR) and without regularization (FSIRB0) were validated against experimental failure loads (Fexp). Statistical iterative reconstruction produced the best quality images with regard to noise, signal-to-noise ratio, and contrast-to-noise ratio. Fexp significantly correlated with FFBP, FSIR, and FSIRB0. FFBP had a significant correlation with FSIRB0 and FSIR. The BMD derived from FBP, SIRB0, and SIR were significantly correlated. Effects of regularization should be further investigated with FE and BMD analysis to allow for an optimal iterative reconstruction algorithm to be implemented in an in vivo scenario.
使用多探测器计算机断层扫描（MDCT）的统计迭代重建（SIR）是标准滤波反投影（FBP）的一种有前景的替代方法，因为在保持图像质量的同时能产生更低的噪声。因此，我们研究了SIR在通过有限元（FE）分析预测基于MDCT的骨矿物质密度（BMD）和椎体骨强度方面的可行性。将使用标准FBP（FFBP）以及带正则化（FSIR）和不带正则化（FSIRB0）的SIR重建的MDCT图像得出的BMD和FE预测骨强度与实验破坏载荷（Fexp）进行验证。在噪声、信噪比和对比噪声比方面，统计迭代重建产生了质量最佳的图像。Fexp与FFBP、FSIR和FSIRB0显著相关。FFBP与FSIRB0和FSIR显著相关。由FBP、SIRB0和SIR得出的BMD显著相关。应通过FE和BMD分析进一步研究正则化的影响，以便在体内场景中实施最佳的迭代重建算法。
