Mookiah Muthu Rama Krishnan, Subburaj Karupppasamy, Mei Kai, Kopp Felix K, Kaesmacher Johannes, Jungmann Pia M, Foehr Peter, Noel Peter B, Kirschke Jan S, Baum Thomas
Radiology.
Neuroradiology, and.
J Comput Assist Tomogr. 2018 May/Jun;42(3):441-447. doi: 10.1097/RCT.0000000000000710.
Multidetector computed tomography-based trabecular bone microstructure analysis ensures promising results in fracture risk prediction caused by osteoporosis. Because multidetector computed tomography is associated with high radiation exposure, its clinical routine use is limited. Hence, in this study, we investigated in 11 thoracic midvertebral specimens whether trabecular texture parameters are comparable derived from (1) images reconstructed using statistical iterative reconstruction (SIR) and filtered back projection as criterion standard at different exposures (80, 150, 220, and 500 mAs) and (2) from SIR-based sparse sampling projections (12.5%, 25%, 50%, and 100%) and equivalent exposures as criterion standard. Twenty-four texture features were computed, and those that showed similar values between (1) filtered back projection and SIR at the different exposure levels and (2) sparse sampling and equivalent exposures and reconstructed with SIR were identified. These parameters can be of equal value in determining trabecular bone microstructure with lower radiation exposure using sparse sampling and SIR.
基于多探测器计算机断层扫描的小梁骨微结构分析在预测骨质疏松症所致骨折风险方面取得了有前景的结果。由于多探测器计算机断层扫描与高辐射暴露相关，其临床常规应用受到限制。因此，在本研究中，我们对11个胸椎中段椎体标本进行了研究，探讨小梁纹理参数是否可从以下方面得出且具有可比性：(1) 使用统计迭代重建(SIR)和滤波反投影重建的图像，以不同曝光量(80、150、220和500 mAs)作为标准对照；(2) 基于SIR的稀疏采样投影(12.5%、25%、50%和100%)以及等效曝光量作为标准对照。计算了24个纹理特征，并确定了在以下两者之间显示相似值的特征：(1) 不同曝光水平下的滤波反投影和SIR；(2) 稀疏采样和等效曝光量，并使用SIR进行重建。这些参数在使用稀疏采样和SIR以较低辐射暴露确定小梁骨微结构方面可能具有同等价值。
