Butlin C Ruth, Pahan David, Maug Aung Kya Jai, Withington Stephen, Nicholls Peter, Alam Khorshed, Salim M D Abdul Hamid
Lepr Rev. 2016 Jun;87(2):171-82.
Duration of leprosy treatment remains long and difficult to complete in resource poor areas. Studies suggest that shortening duration of therapy for MB patients to 6 months may be possible.
New MB patients in 2005 in two NGO projects in Bangladesh were treated with 6 months WHO MB MDT and the rate of relapse and fall in BI on slit skin smear during follow up to date were compared with a control group treated for 12 months the previous year.
1612 patients were enrolled in the trial, and the average duration of follow up was over 7 years after diagnosis. During 11,425 PYAR of follow-up, no relapses were detected, by bacteriological or clinical criteria, in the 918 patients in the 6 months MB MDT group, nor in the 694 patients in the control group. Rate of decline of BI in those who were smear positive was not significantly different between groups.
The data does not suggest that shortening duration of treatment from 2 months to 6 months MDT for MB leprosy patients leads to increased rates of relapse.
在资源匮乏地区，麻风病治疗疗程仍然很长且难以完成。研究表明，将多菌型（MB）患者的治疗疗程缩短至6个月或许可行。
2005年在孟加拉国两个非政府组织项目中的新多菌型患者接受了为期6个月的世界卫生组织多菌型联合化疗（MDT），并将截至目前随访期间的复发率和皮肤涂片细菌指数（BI）下降情况与前一年接受12个月治疗的对照组进行比较。
1612名患者参与了该试验，诊断后平均随访时间超过7年。在11425人年的随访期间，根据细菌学或临床标准，6个月多菌型联合化疗组的918名患者以及对照组的694名患者均未检测到复发。涂片阳性患者的细菌指数下降率在两组之间无显著差异。
数据并不表明将多菌型麻风病患者的治疗疗程从12个月缩短至6个月会导致复发率增加。
