Lewis D, Teyler T J
Brain Res. 1986 Sep 24;383(1-2):159-64. doi: 10.1016/0006-8993(86)90016-8.
S-100 is a calcium-binding, glial protein which has been shown to be involved in behavioral learning and memory tasks. Long-term potentiation (LTP) in the hippocampus is a long-lasting enhancement of synaptic efficacy evoked by repetitive afferent stimulation. When anti-S-100 serum is applied by pressure ejection onto the stratum radiatum of area CA1 of the hippocampal slice, the amplitude of the extracellularly recorded population spike is not affected. However, repetitive stimulation of the afferents during S-100 application failed to produce LTP. At a distant site in the same slice, LTP occurs normally. Preimmune normal rabbit serum had no effect on the development of LTP. It appears that S-100 protein is involved in the establishment of LTP.
S-100是一种钙结合神经胶质蛋白，已被证明与行为学习和记忆任务有关。海马体中的长时程增强（LTP）是由重复传入刺激引起的突触效能的长期增强。当通过压力喷射将抗S-100血清施加到海马切片CA1区辐射层时，细胞外记录的群体峰电位的幅度不受影响。然而，在施加S-100期间重复刺激传入神经未能产生LTP。在同一切片的远处部位，LTP正常发生。免疫前正常兔血清对LTP的发展没有影响。看来S-100蛋白参与了LTP的建立。
