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非病毒血症性猫白血病病毒感染猫中性粒细胞功能降低的证明

Demonstration of depressed polymorphonuclear leukocyte function in nonviremic FeLV-infected cats.

作者信息

Lafrado L J, Olsen R G

出版信息

Cancer Invest. 1986;4(4):297-300. doi: 10.3109/07357908609017509.

DOI:10.3109/07357908609017509
PMID:3021292
Abstract

Polymorphonuclear leukocytes (PMN) from healthy, normal control cats and FeLV-infected cats were analyzed for differences in phagocytic capabilities. One week after experimental infection, PMNs from FeLV-infected cats exhibited a marked decrease in phagocytic function as determined by the luminol-dependent chemiluminescent response. Depressed PMN function was observed in these cats during the viremic stage of infection and subsequently remained depressed after the cessation of viremia. The data presented here suggest that while nonviremic cats are reported as clinically normal, they may in fact be exhibiting a suppressed PMN function.

摘要

对来自健康正常对照猫和感染猫白血病病毒(FeLV)的猫的多形核白细胞(PMN)进行吞噬能力差异分析。实验感染一周后,通过鲁米诺依赖性化学发光反应测定,感染FeLV的猫的PMN吞噬功能显著下降。在这些猫的病毒血症感染阶段观察到PMN功能降低,并且在病毒血症停止后随后仍保持降低。此处呈现的数据表明,虽然非病毒血症猫在临床上被报告为正常,但它们实际上可能表现出PMN功能受到抑制。

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